AI Article Synopsis
- Variants of the serotonin transporter gene SLC6A4, particularly the short variant (5-HTTLPR SS genotype), are linked to higher likelihoods of depression and anxiety.
- Subjects with the SS genotype experienced a more significant increase in cortisol levels after being subjected to the Montreal Imaging Stress Task, compared to those with at least one long variant.
- Brain imaging showed that the SS genotype was associated with greater activation in several regions, including the dorsomedial prefrontal cortex and anterior insula, indicating heightened brain response to stress.
Article Abstract
Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.
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| http://dx.doi.org/10.1016/j.physbeh.2020.112876 | DOI Listing |
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