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Exploiting spatial isomerism to modulate the assembled phase and rheological response of compositionally identical sugar-based surfactants.
Chem Sci
January 2025
Center for Research in Biological Chemistry and Molecular Materials (CIQUS), Department of Chemical Engineering, Universidade de Santiago de Compostela Rúa de Jenaro de la Fuente, s/n 15705 Santiago de Compostela Spain
For decades, extensive surfactant libraries have been developed to meet the requirements of downstream applications. However, achieving functional diversity has traditionally demanded a vast array of chemical motifs and synthetic pathways. Herein, a new approach for surfactant design based on structural isomerism is utilised to access a wide spectrum of functionalities.
View Article and Find Full Text PDFA physicochemical investigation of the complex formation by β-cyclodextrin with Triton X-100 and Triton X-114 and their aggregation behaviour in aqueous solution: an experimental approach.
Phys Chem Chem Phys
January 2025
Centre for Surface Science, Physical Chemistry Section, Department of Chemistry, Jadavpur University, Kolkata-700032, West Bengal, India.
The complexation behavior and binding affinity of Triton X-100 (TX-100) and Triton X-114 (TX-114) with β-cyclodextrin (β-CD) were extensively studied in an aqueous medium using a comprehensive suite of experimental techniques. These techniques allowed for the evaluation of key physicochemical parameters, including critical micelle concentration (cmc), aggregation number (), Stern-Volmer constant, and particle size distribution. These metrics were instrumental in understanding the underlying mechanism of the host-guest interaction between β-CD and Triton-X.
View Article and Find Full Text PDFStructure-activity relationship of peptide conjugates derived from BP100 and insights into their interactions with lipid membranes by NMR and MD simulations.
J Biomol Struct Dyn
January 2025
LIPPSO, Department of Chemistry, Campus Montilivi, Universitat de Girona, Girona, Spain.
Antimicrobial and plant defence elicitor peptides have received attention on last decades as novel tools to combat bacterial plant diseases. We previously reported a library of peptide conjugates resulting from the combination of an antimicrobial peptide (, , or ) and a plant defence elicitor sequence (, , or ). From this library, we selected a set of 14 peptide conjugates including both highly and poorly active sequences and we performed a structure-activity relationship study by NMR and MD simulations.
View Article and Find Full Text PDFMolecular Interactions of the Antimicrobial Peptide Tritrpticin with Mixed Nanoaggregates: A Fluorescence Spectroscopy Study.
Protein Pept Lett
January 2025
Department of Exact Sciences, State University of Santa Cruz - UESC, Rodovia Jorge Amado Km 16, CEP: 45662-900, Ilhéus - BA, Brazil.
Introduction: Tritrpticin (TRP3) is a peptide belonging to the cathelicidin family and has a broad spectrum of antimicrobial activity. However, this class of biomolecules can be easily degraded in the body, making it necessary to use an efficient transport system. The ability to form stable nanostructures from the interaction of glycyrrhizin saponin with the pluronic polymer F127 was demonstrated, forming mixed biopolymeric micelles, highly promising as drug carriers.
View Article and Find Full Text PDFPSMA-targeted delivery of docetaxel in prostate cancer using small-sized PDA-based micellar nanovectors.
J Control Release
January 2025
Asymmetric Synthesis and Functional Nanosystems Group (Art&Fun), Institute of Chemical Research (IIQ), CSIC-University of Seville, C/ Américo Vespucio 49, 41092 Seville, Spain. Electronic address:
In this study, we present the first comparative analysis of active and passive drug delivery systems for docetaxel (DTX) in prostate cancer using supramolecular self-assembled micellar nanovectors. Specifically, we developed two novel micelles based on polydiacetylenic amphiphiles (PDA) for passive and active targeting. The active targeting micelles were designed with a prostate-specific membrane antigen (PSMA) ligand, ACUPA, to facilitate recognition by PSMA-positive cancer cells.
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