Adv Ther
Health Economics and Outcomes Research, STATinMED Research, Ann Arbor, MI, USA.
Published: May 2020
Introduction: Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. This real-world study evaluated persistence, dose titration, health care resource utilization (HCRU) and associated costs, and medication use among CD patients treated with ustekinumab (UST) in several pooled US commercial database populations.
Methods: CD patients aged ≥ 18 years with medical or pharmacy claims for UST were selected from pooled data from 3 large, national commercial databases. The first observed medical or pharmacy claim for UST was the index date. Patients were required to have had ≥ 1 medical claim with a CD diagnosis during the 12 months prior to the index date and continuous health plan enrollment for a minimum of 12 months prior to and 12 months after the index date. Comparisons of outcomes during the baseline and follow-up periods were conducted using inferential statistical tests.
Results: A total of 214 eligible UST patients were selected. The majority (74.8%) were biologic experienced (mean age: 41 years), and 83.6% remained treatment persistent during the 12-month post-index period. Among discontinuers, 25.7% restarted UST, and 8.6% switched from UST in the 12-month observation period. The mean treatment duration was 329 days. Most patients (77%) used the recommended UST dose, as defined as being within a 20% dose variation from label (90 mg/8 weeks ± 20%), 17.9% experienced dose escalation, and 5.1% experienced dose reduction. Post-index immunomodulator and corticosteroid use reduced by 20% and 28%, respectively, as compared with pre-index use among CD patients using UST. Annual all-cause ER visits and inpatient stays decreased by 20.5% and 30.3%, respectively, with similar downward trends for annual CD-related HCRU.
Conclusions: The majority of CD patients prescribed UST were biologic experienced, and persistence was high over the 1-year follow-up. UST treatment initiation was associated with reductions in ER visits, inpatient stays, and steroid and other medication use.
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http://dx.doi.org/10.1007/s12325-020-01276-3 | DOI Listing |
J Affect Disord
January 2025
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Background And Objective: To determine whether there is disproportionate reporting of hepatobiliary disorders in the United States (US) FDA Adverse Event Reporting System (FAERS) for individuals prescribed ketamine or esketamine.
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Mol Neurodegener
January 2025
Center for Cognition and Sociality, Life Science Institute (LSI), Institute for Basic Science (IBS), Daejeon, Republic of Korea.
Background: Alzheimer's Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic GABA and HO are associated with memory impairment in AD and synthesized through the Monoamine Oxidase B (MAOB)-mediated multi-step degradation of putrescine. However, the enzymes downstream to MAOB in this pathway remain unidentified.
View Article and Find Full Text PDFSmall Methods
January 2025
Nano Hybrid Technology Research Center, Electrical Materials Research Division, Korea Electrotechnology Research Institute (KERI), Changwon, 51543, Republic of Korea.
The conventional carbonization process for synthesizing hard carbons (HCs) requires high-temperature furnace operations exceeding 1000 °C, leading to excessive energy consumption and lengthy processing times, which necessitates the exploration of more efficient synthesis methods. This study demonstrates the rapid preparation of HC anodes using intense pulsed light (IPL)-assisted photothermal carbonization without the prolonged and complex operations typical of traditional carbonization methods. A composite film of microcrystalline cellulose (MCC) and single-walled carbon nanotubes (SWCNTs) is carbonized at high temperatures in less than 1 min.
View Article and Find Full Text PDFPhysiol Meas
January 2025
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, No.28 west Xianning Rd, Xi'an, 710049, CHINA.
The transient autonomic nervous system responses induced by electroconvulsive therapy (ECT) may serve as critical indicators of treatment efficacy and potential side effects; however, their precise characteristics remains unclear. Considering that the intense stimulation of ECT may disrupt the typical antagonistic relationship between the sympathetic and parasympathetic branches, this study aims to conduct a meticulous analysis of the rapid changes in heart rate variability and heart rate during ECT, with a particular focus on their synchronized interplay. Methods: Pulse interval sequences were collected from fifty sessions of bitemporal ECT administered to twenty-seven patients diagnosed with major depressive disorder.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China.
Polymer electrolyte membrane fuel cells (PEMFCs) are one of the most promising energy conversion devices due to their high efficiency and zero emission; however, two major challenges, high cost and short lifetime, have been hindering the commercialization of fuel cells. Achieving low-Pt or non-precious metal oxygen reduction reaction (ORR) electrocatalysts is one of the main research ideas in this field. In this review, the degradation mechanism of Pt-based catalysts is firstly explained and elucidated, and then five strategies are suggested for the reduction of Pt usage without loss of activity and durability: modulation of metal-support interactions, optimization of local ionomers and mass transport, modulation of composition, modulation of structure, and multi-site synergistic effects.
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