AI Article Synopsis
- Most research on ionizing radiations in cancer treatment has primarily focused on the ionization process, overlooking the effects of excitation events.
- This study utilizes a novel cathodoluminescence system to analyze the excited states of DNA when exposed to accelerated electrons in the picosecond time frame.
- Findings indicate both qualitative differences and quantitative similarities between DNA's excited states under electron and photon exposure, highlighting the importance of understanding these processes.
Article Abstract
Despite the tremendous importance of so-called ionizing radiations (X-rays, accelerated electrons and ions) in cancer treatment, most studies on their effects have focused on the ionization process itself, and neglect the excitation events the radiations can induce. Here, we show that the excited states of DNA exposed to accelerated electrons can be studied in the picosecond time domain using a recently developed cathodoluminescence system with high temporal resolution. Our study uses a table-top ultrafast, UV laser-triggered electron gun delivering picosecond electron bunches of keV energy. This scheme makes it possible to directly compare time-resolved cathodoluminescence with photoluminescence measurements. This comparison revealed qualitative differences, as well as quantitative similarities between excited states of DNA upon exposure to electrons or photons.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081262 | PMC |
| http://dx.doi.org/10.1038/s41598-020-61711-x | DOI Listing |
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