AI Article Synopsis
- * The study conducted a genome-wide association study (GWAS) involving over 47,000 Caucasian individuals to explore the relationship between lean mass and the FTO gene, which is linked to obesity.
- * The findings identified 29 specific genetic variations (SNPs) in the FTO gene that are significantly associated with sarcopenia, suggesting that FTO may play a role in lean muscle mass.
Article Abstract
Sarcopenia is characterized by low skeletal muscle, a complex trait with high heritability. With the dramatically increasing prevalence of obesity, obesity and sarcopenia occur simultaneously, a condition known as sarcopenic obesity. Fat mass and obesity-associated (FTO) gene is a candidate gene of obesity. To identify associations between lean mass and FTO gene, we performed a genome-wide association study (GWAS) of lean mass index (LMI) in 2207 unrelated Caucasian subjects and replicated major findings in two replication samples including 6,004 unrelated Caucasian and 38,292 unrelated Caucasian. We found 29 single nucleotide polymorphisms (SNPs) in FTO significantly associated with sarcopenia (combined p-values ranging from 5.92 × 10 to 1.69 × 10). Potential biological functions of SNPs were analyzed by HaploReg v4.1, RegulomeDB, GTEx, IMPC and STRING. Our results provide suggestive evidence that FTO gene is associated with lean mass.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081265 | PMC |
| http://dx.doi.org/10.1038/s41598-020-61406-3 | DOI Listing |
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