is a leading cause of otitis media and exacerbations of chronic obstructive pulmonary disease; however, its response to iron starvation during infection is not completely understood. Here, we announce a sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) data set describing the differential expression of the CCRI-195ME proteome under iron-restricted versus iron-replete conditions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082453 | PMC |
| http://dx.doi.org/10.1128/MRA.00064-20 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics.
PLoS One
January 2025
National Marine Science Centre, Southern Cross University, Coffs Harbour, NSW, Australia.
Discovering new antibiotics and increasing the efficacy of existing antibiotics are priorities to address antimicrobial resistance. Antimicrobial proteins and peptides (AMPPs) are considered among the most promising antibiotic alternatives and complementary therapies. Here, we build upon previous work investigating the antibacterial activity of a semi-purified hemolymph protein extract (HPE) of the Australian oyster Saccostrea glomerata.
View Article and Find Full Text PDFProteomics and Microbiota Conjoint Analysis in the Nasal Mucus: Revelation of Differences in Immunological Function in and .
Animals (Basel)
September 2024
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China.
All eight pangolin species, especially captive , are critically endangered and susceptible to various pathogenic microorganisms, causing mass mortality. They are involved in the complement system, iron transport system, and inflammatory factors. exhibited a higher abundance of opportunistic pathogens, , which potentially evaded complement-mediated immune response by reducing C5 levels and counteracting detrimental effects through transferrin neutralization.
View Article and Find Full Text PDFA Multimodal System for Lipid A Structural Analysis from a Single Colony.
Anal Chem
August 2024
Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland 21201, United States.
Structural elucidation of Gram-negative bacterial lipid A traditionally requires chemical extraction followed by tandem MS data in the negative ion mode. Previously, we reported FLAT and FLAT as methods to rapidly determine the structure of lipid A without chromatographic techniques. In this work, we extend the capability and effectiveness of these techniques to elucidate the chemical structure in a de novo manner by including the use of positive ion mode (FLAT and FLAT) spectral approaches.
View Article and Find Full Text PDFEndotypes of severe neutrophilic and eosinophilic asthma from multi-omics integration of U-BIOPRED sputum samples.
Clin Transl Med
July 2024
National Heart and Lung Institute, Imperial College London, London, UK.
Background: Clustering approaches using single omics platforms are increasingly used to characterise molecular phenotypes of eosinophilic and neutrophilic asthma. Effective integration of multi-omics platforms should lead towards greater refinement of asthma endotypes across molecular dimensions and indicate key targets for intervention or biomarker development.
Objectives: To determine whether multi-omics integration of sputum leads to improved granularity of the molecular classification of severe asthma.
Infant Bronchiolitis Endotypes and the Risk of Developing Childhood Asthma: Lessons From Cohort Studies.
Arch Bronconeumol
April 2024
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- * Recent studies using unbiased analytical methods have identified new subtypes of bronchiolitis that are at a higher risk for asthma, such as a specific endotype associated with RSV and certain bacteria.
- * The findings from these studies are important for the development of new treatments for bronchiolitis and strategies for asthma prevention, but they still need further validation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!