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[Translated article] Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases.
Farm Hosp
February 2023
Servicio de Farmacia, Hospital General universitario Gregorio Marañón, Madrid, Spain.
Objective: The objective of this review is to gather the available evidence on the different drugs used in immune-mediated inflammatory diseases in pregnancy, lactation, their influence on female and male fertility, advice on discontinuation before conception and to help in routine clinical practice for better patient advice on family planning.
Methods: A bibliographic search was carried out, where published articles (review studies, observational studies and case series) in English or Spanish until April 2020 that analyzed the management of pregnancy, lactation and/or fertility in patients on treatment in immune-mediated diseases were selected.
Results: A total of 95 references were selected and the information on each drug was synthesized in tables.
Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases.
Farm Hosp
February 2023
Servicio de Farmacia, Hospital General Universitario Gregorio Marañón, Madrid, España.
Objective: The objective of this review is to gather the available evidence on the different drugs used in immune-mediated inflammatory diseases in pregnancy, lactation, their influence on female and male fertility, advice on discontinuation before conception and to help in routine clinical practice for better patient advice on family planning.
Methods: A bibliographic search was carried out, where published articles (review studies, observational studies and case series) in English or Spanish until April 2020 that analyzed the management of pregnancy, lactation and/or fertility in patients on treatment in immune-mediated diseases were selected.
Results: A total of 95 references were selected and the information on each drug was synthesized in tables.
Planifier une grossesse chez une patiente avec un psoriasis.
Eur J Dermatol
October 2020
Service de Dermatologie, CHU Brest, Brest, France, Laboratoire interactions épithéliums-neurones, EA 4685, université Brest Occidentale, France.
Psoriasis is a common inflammatory skin disease that starts before the age of 40 years in 3/4 cases. Pregnancy in a couple where one of the future parents has psoriasis is therefore a frequent situation that the dermatologist may encounter and must anticipate. Contraception should be systematically discussed with psoriatic patients of childbearing age, as it is mandatory with certain treatments (as methotrexate or acitretin).
View Article and Find Full Text PDFPaternal acitretin exposure and the risk of miscarriage and major congenital malformations: A nationwide register-based cohort study.
J Am Acad Dermatol
July 2020
Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review.
J Am Acad Dermatol
April 2019
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:
Background: This systematic review assesses effects of paternal exposure to dermatologic medications by using the former US Food and Drug Administration (FDA) pregnancy categories as a benchmark.
Objective: To assess whether systemic dermatologic medications can cause infertility and teratogenicity when taken by men.
Methods: Categories D and X dermatologic medications were identified; a systematic review of the literature and reviews of the FDA Adverse Events Reporting System and prescribing information were performed to identify the effects of these medications on male fertility and teratogenicity.
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