Dopaminergic Control over the Tripartite Synapse.

Neuron

Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA. Electronic address:

Published: March 2020

In this issue of Neuron, Corkrum et al. (2020) demonstrate an unexpected role for dopamine D receptors on astrocytes located in the nucleus accumbens, a key structure of the brain's reward system. Activation of these receptors mediates dopamine-evoked depression of excitatory synaptic transmission, which contributes to amphetamine's psychomotor effects.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175810PMC
http://dx.doi.org/10.1016/j.neuron.2020.02.031DOI Listing

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