AI Article Synopsis
- The compound benidipine hydrochloride (KW-3049) is a potent calcium antagonist and was analyzed for various physical and chemical properties, including melting point and spectral data (UV, IR, NMR, MS).
- Its stability under different conditions was evaluated using high-performance liquid chromatography (HPLC), showing strong resistance to heat and moisture, as well as moderate resistance to light.
- Additionally, the study included assessments of solubility, pKa, partition coefficient, and various chromatography techniques (TLC, HPLC).
Article Abstract
(+/-)-(R*)-2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarboxylic acid (R*)-1-benzyl-3-piperidinyl ester, methyl ester hydrochloride (benidipine hydrochloride, KW-3049), a highly potent calcium antagonist, was examined to clarify its physico-chemical properties, i.e. melting point, spectra (UV, IR, NMR, MS), X-ray diffraction pattern, thermal analysis, solubilities, pKá, partition coefficient and chromatography (TLC, HPLC). The stabilities of KW-3049 were studied under various conditions by HPLC. KW-3049 in solid state was very stable to heat and moisture, and fairly stable to light.
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