Synthesis of cardiolipin analogues containing an ionophore residue in the fatty acid moiety is described. The ionophore, dibenzo-18-crown-6, has been incorporated into second position of the glycerol residue by acylating mono- and dilysocardiolipin with a modified fatty acid anhydride. Lyso-derivatives of cardiolipin have been prepared by enzymatic hydrolysis of beef heart cardiolipin by snake venom phospholipase A2 (Naja naja oxiana).
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