AI Article Synopsis
- The study investigates the relationship between coagulation factor V gene polymorphisms and cancer, specifically looking into its prognostic significance in gastric cancer (GC).
- Using RNA-sequencing data from The Cancer Genome Atlas (TCGA), researchers found that the expression levels of the coagulation factor V gene were notably higher in GC samples.
- Survival analysis indicated that patients with high levels of this gene had shorter overall survival, suggesting it could serve as a potential biomarker for prognosis in gastric cancer patients.
Article Abstract
Association of Coagulation factor V () polymorphisms with the occurrence of many types of cancers has been widely reported, but whether it is of prognostic relevance in some cancers remain to be resolved. The RNA-sequencing dataset was downloaded from The Cancer Genome Atlas (TCGA). The potential of genes to predict the survival time of gastric cancer (GC) patients was investigated using univariate and multivariate survival analysis whereas "Kaplan-Meier plotter" (KM-plotter) online tools were employed to validate the outcomes. TCGA data revealed that levels were significantly upregulated in gastric cancer samples. Survival analysis confirmed that high levels of correlated with short overall survival (OS) in gastric cancer patients, and the area under the curve (AUC) values of 1-, 2-, and 5-year OS rate were 0.554, 0.593, and 0.603, respectively. Survival analysis by KM-plotter indicated that the high expression of was significantly associated with a shorter OS compared with the low expression level in all patients with GC, and this was also the case for patients in stage III (hazard ratio (HR) = 1.78, = 0.017). These findings suggest that the gene is significantly upregulated in GC tumour tissues, and may be a potential prognostic biomarker for GC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064826 | PMC |
| http://dx.doi.org/10.1155/2020/9280841 | DOI Listing |
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