In the experiment, performed on dogs ultrastructure of the ischiatic nerve allograft, preserved in liquid nitrogen (-196 degrees) has been studied. In 7 days after the operation in the transplanted piece of the nerve trunk certain phenomena, similar to the Wallerian degeneration are noted, while viability of neurilemma cells is preserved. Processes of second degeneration are mainly completed by the end of the first month after the operation. During this time active regeneration of nervous fibers is noted; it is accompanied with neutralization of the graft. The latter is mostly expressed in 6 months after the operation. The dynamics studied on ultramicroscopic rearrangements of the cryopreserved graft proves the previously obtained data on possibility of its use in clinics for substitution of defects in peripheral nerves.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Oral health and rehabilitation in face transplant recipients - a systematic review.
Clin Oral Investig
January 2025
Department of Cranio- and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Article Synopsis
- Facial transplantation (FT) aids in severe facial defects by using complex tissues, making oral health crucial for successful outcomes, but there's limited research in this area.
- A systematic review identified 19 relevant studies out of nearly 7,000 articles, with most cases being male and originating from the U.S. and France, highlighting common oral issues like malocclusion.
- Routine oral health evaluations are vital for FT patients to avoid complications, but more high-quality research is necessary to set standardized care practices.
Introduction: Available therapies for peripheral nerve injury (PNI) include surgical and non-surgical treatments. Surgical treatment includes neurorrhaphy, grafting (allografts and autografts) and tissue-engineered grafting (artificial nerve guide conduits), while non-surgical treatment methods include electrical stimulation, magnetic stimulation, laser phototherapy and administration of nerve growth factors. However, the treatments currently available to best manage the different PNI manifestations remain undetermined.
View Article and Find Full Text PDFRepair of Acute Grade-3 Combined Posterolateral Corner Avulsion Injuries Using a Transosseous Krackow Suture Pull-Through Technique.
JBJS Essent Surg Tech
December 2024
Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut.
Background: For complete disruption of the posterolateral corner (PLC) structures, operative treatment is most commonly advocated, as nonoperative treatment has higher rates of persistent lateral laxity and posttraumatic arthritis. Some studies have shown that acute direct repair results in revision rates upwards of 37% to 40% compared with 6% to 9% for initial reconstruction. In a recent study assessing the outcomes of acute repair of PLC avulsion injuries with 2 to 7 years of follow-up, patients with adequate tissue were shown to have a much lower failure rate than previously documented.
View Article and Find Full Text PDFNerve regeneration using a Bio 3D conduit derived from umbilical cord-Derived mesenchymal stem cells in a rat sciatic nerve defect model.
PLoS One
December 2024
Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan.
Unlabelled: Human umbilical cord-derived mesenchymal stromal cells (UC-MSCs), which can be prepared in advance and are presumed to be advantageous for nerve regeneration, have potential as a cell source for Bio 3D conduits. The purpose of this study was to evaluate the nerve regeneration ability of Bio 3D conduits made from UC-MSCs using a rat sciatic nerve defect model.
Methods: A Bio 3D conduit was fabricated using a Bio 3D printer by placing UC-MSC spheroids into thin needles according to predesigned 3D data.
Challenges in the surgical treatment of neuroma in continuity in the upper extremity using human acellular nerve allografts.
J Plast Reconstr Aesthet Surg
November 2024
Department of Hand Surgery, Herlev/Gentofte University Hospital of Copenhagen, Hospitalsvej 1, 2900 Hellerup, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Institute of Clinical Medicine, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
The restoration of nerve function after the injury might be complicated by the development of a disorganized fibrous mass-a neuroma. This results in sensory and/or motor deficits and pain that can be severely debilitating. Surgical excision of the painful neuroma may leave a gap, which can be bridged using autografts or allografts.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!