AI Article Synopsis
- West Nile virus was first identified in the U.S. in 1999, isolated from specific mosquito species Culex pipiens pipiens and Aedes vexans.
- A Connecticut strain of Ae. vexans was shown to effectively transmit the virus both to suckling mice and to its offspring in laboratory settings.
- Transmission rates increased over time, with high horizontal transmission rates observed by days 28-30 post-exposure, while vertical transmission was noted after the mosquito's third bloodmeal, potentially helping the virus survive winter.
Article Abstract
West Nile virus (family Flaviviridae, genus Flavivirus) first caused human and veterinary disease, and was isolated from Culex pipiens pipiens L. and Aedes vexans (Meigen) (Diptera: Culicidae) in the United States in 1999. We report that a Connecticut strain of Ae. vexans was competent to transmit West Nile virus both horizontally to suckling mice and vertically to its progeny in the laboratory. Horizontal transmission was first observed on day 6 post-exposure (pe). Daily horizontal transmission rates generally increased with the day post-virus exposure with highest rates of 67-100% recorded on days 28-30 pe. One female vertically transmitted West Nile virus on day 21 pe, but only after it had taken its third bloodmeal. Horizontal and vertical transmission may contribute to West Nile virus infection rates in Ae. vexans in summer, and vertical transmission provides a means of survival of West Nile virus during winter.
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| http://dx.doi.org/10.1093/jme/tjaa049 | DOI Listing |
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