AI Article Synopsis
- Advances in treatment have significantly improved survival rates for individuals with single ventricle heart disease, leading to approximately 70,000 patients worldwide living with Fontan circulation, many of whom are now over 18 years old.
- About 75% of Fontan patients can expect to survive at least until 30 years of age, reflecting these medical advancements.
- Despite these improvements, single ventricle patients make up a large percentage of children hospitalized for circulation failure in the U.S., facing high mortality rates and a lack of understanding regarding their condition, which hampers the development of effective long-term treatments.
Article Abstract
Abstracts Because of remarkable advances in survival over the past 40 years, the worldwide population of individuals with single ventricle heart disease living with Fontan circulation has grown to ≈70 000, with nearly half aged >18 years. Survival to at least 30 years of age is now achievable for 75% of Fontan patients. On the other hand, single ventricle patients account for the largest group of the 6000 to 8000 children hospitalized with circulation failure, with or without heart failure annually in the United States, with the highest in-hospital mortality. Because there is little understanding of the underlying mechanisms of heart failure, arrhythmias, pulmonary and lymphatic vascular abnormalities, and other morbidities, there are no specific treatments to maintain long-term myocardial performance or to optimize overall patient outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428620 | PMC |
| http://dx.doi.org/10.1161/JAHA.119.015871 | DOI Listing |
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