AI Article Synopsis

  • PRRSV (Porcine reproductive and respiratory syndrome virus) significantly impacts pig health, leading to reproductive failures in sows and respiratory issues in piglets, causing high mortality rates and economic losses, especially concerning a new strain in China.
  • The novel PRRSV-ZDXYL-China-2018-1 strain was found to cause symptoms such as persistent fever, respiratory distress, and pneumonia in piglets, indicating its pathogenic nature.
  • The study emphasizes the urgent need for effective control strategies to manage PRRSV spread in the affected regions, highlighting both the severity of infection and the inflammatory responses observed in infected pig lungs.

Article Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus that causes reproductive failure in sows and respiratory problems in piglets. PRRSV infection leads to substantial pig mortality and causing huge economic losses so that disease outbreaks caused by the new PRRSV strain from other regions have caused great concern in China. In this study, we analysed the pathogenicity of the novel ORF5 RFLP 1-7-4-like PRRSV strain, named PRRSV-ZDXYL-China-2018-1 in pigs. The viral challenge test showed that PRRSV-ZDXYL-China-2018-1 infection can cause persistent fever, moderate dyspnoea, serum viraemia and interstitial pneumonia in piglets. The levels of viral loads in serum and PRRSV-specific antigen were also detected in lung tissues were used one-step Taq-Man RT-qPCR and Immunohistochemistry, respectively. At 28dpi, the level of specific antibodies was increased among infected piglets. Importantly, the new virus appeared be a moderately virulent isolate with pathogenicity compared to HP-PRRSV strain LQ (JXA1-like strain). Histological examination revealed severe monocyte haemorrhage and interstitial pneumonia associated with monocyte infiltration in the lung tissue of pigs infected with PRRSV-ZDXYL-China-2018-1 and LQ-JXA1 strains. Immunohistochemistry (IHC) results showed positive brown-red epithelial cells and macrophages in pig lungs. Therefore, it is critical to establish an effective strategy to control the spread of PRRSV in China.

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http://dx.doi.org/10.1111/tbed.13549DOI Listing

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