Discovery of Potent -Ethylurea Pyrazole Derivatives as Dual Inhibitors of and .

() and () are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people around the world. Current treatments are unsatisfactory, frequently associated with intolerable side-effects, and generally inadequate in treating all stages of disease. In this paper, we report the discovery of -ethylurea pyrazoles that potently and selectively inhibit the viability of and . Sharp and logical SAR led to the identification of as the best compound, with an IC of 9 nM and 16 nM against and , respectively. Compound demonstrates favorable physicochemical properties and was efficacious in a murine model of Chagas disease, leading to undetectable parasitemia within 6 days when CYP metabolism was inhibited.