Chaharmahal and Bakhtiari Province is one of the most important endemism states of the flora of Iran with a considerable plant species diversity. In the present study, the cytotoxic activity of 13 plant species grown in Chaharmahal and Bakhtiari have been evaluated on prostate (PC-3), breast (MCF-7), liver (HepG2), ovary (CHO), and melanoma (B16-F10) cancer cell lines. The cytotoxicity and apoptotic activity of methanol extracts was evaluated using resazurin reagent and flow cytometry of PI stained cells, respectively. Methanol extracts of , and on CHO cell line ( <0.05) and and on B16/F10 cell line ( <0.05) showed significant cytotoxic effects and increased apoptosis. It is generally suggested that the plant extracts with low IC values are likely to be used as anti-cancer compounds in reducing cancer progression in scientific studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059058 | PMC |
| http://dx.doi.org/10.22037/ijpr.2019.14665.12599 | DOI Listing |
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