Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165477 | PMC |
| http://dx.doi.org/10.1073/pnas.2000032117 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of supramolecular ionic gels with self-healing capability and biodegradability using a bioderived ionic liquid and poly(vinyl alcohol).
Nanoscale
December 2024
Department of Electrical and Electronic Engineering, Kyushu Institute of Technology, 1-1 Sensuicho, Tobataku, Kitakyushushu, Fukuoka 804-8550, Japan.
Gels are promising candidates for environmental sensing and implants because of their high stretchability, ionic conductivity, and low toxicity toward the environment and human body. Self-healing gels can recover their mechanical and electrical properties after rupturing under environments with harsh mechanical stress. However, current self-healing gels rely on healing agents, metal ions, or dynamic bonding; these materials exhibit toxicity and nonbiodegradability, hindering their use in environmental sensing and implant applications.
View Article and Find Full Text PDFSynthesis, characterization and irritant effects of nonivamide irritant riot control agent based on ionic liquids.
Front Chem
November 2024
State key Laboratory of NBC Protection for Civilian, Beijing, China.
Active Pharmaceutical Ingredients-Ionic liquids (API-ILs) can increase drug solubility and bioavailability of solid drugs without changing the structure of drug molecules. In the present work, nonivamide (pelargonic acid vanillylamide, PAVA) was used as the active drug and choline (Ch) and citric acid (CA) were selected as the ions to prepare PAVA-based ionic liquid ([Ch][PAVA] and [PAVA] [CA]), respectively. The characterization and physical properties of [Ch][PAVA] and [PAVA] [CA], such as FT-IR spectra, 1H NMR spectra, thermal stability and hydrophilicity, were investigated.
View Article and Find Full Text PDFInteraction between newly synthesized surface-active ionic liquids with pharmaceutically active anion and bovine serum albumin.
Int J Biol Macromol
December 2024
Department of Physical Chemistry, Kazan Federal University, Kremlyovskaya str.18, Kazan 420008, Russian Federation.
Article Synopsis
- - This study focuses on new ionic liquids derived from imidazolium and choline containing 5-fluorouracil, exploring their effects on the structure and binding behavior with bovine serum albumin (BSA) using techniques like circular dichroism (CD) and fluorescence quenching.
- - The research investigates how the length of alkyl chains in these ionic liquids impacts their interaction with BSA and their aggregation tendencies through dynamic light scattering (DLS).
- - Results reveal that longer alkyl chains do not enhance binding to BSA, but one specific compound showed selectivity against cancer cells that regular 5-fluorouracil lacks, suggesting potential benefits in cancer treatment.
Synthesis of novel deep eutectic solvent-modified nano cellulosic gel formulation-based strain sensor for human motion monitoring.
Int J Biol Macromol
January 2025
School of Chemistry Materials Engineering, Zhejiang A&F University, Zhejiang Province, Hangzhou 10341, PR China.
Using deep eutectic solvents (DES) to pretreat wheat straw (WS) and extract lignin-containing nanocellulose (LCNC). Acrylic acid/choline chloride (AA/ChCl) polymerizable deep eutectic solvents (PDES) were used as the primary polymerization network, combined with polyvinyl alcohol (PVA). Lignocellulose nanocrystals (LCNC) oxidized by sodium periodate were prepared as dialdehyde-based nanocellulose (DCNC) to serve as the crosslinking agent.
View Article and Find Full Text PDFDelivery of small interfering RNA by hydrogen sulfide-releasing nanomotor for the treatment of Parkinson's disease.
J Control Release
January 2025
National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Institute for Life and Health, Nanjing Drum Tower Hospital, Nanjing Normal University, Nanjing 210023, China. Electronic address:
Article Synopsis
- Small interfering RNA (siRNA) shows promise for treating Parkinson's disease by inhibiting the formation of harmful α-synuclein aggregates, but challenges like low stability and difficulty crossing the blood-brain barrier limit their effectiveness.
- Researchers created an HS donor nanomotor that encapsulates siRNA, protecting its activity and targeting it to damaged mitochondria in neurons, enhancing therapeutic outcomes.
- The nanomotor combines two specific polymers to cross the blood-brain barrier and specifically target damaged cells, allowing it to silence the α-syn gene and degrade existing aggregates, which could potentially reverse Parkinson's disease pathology.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!