AI Article Synopsis
- - The study explores how exposure to oxidative stress in early development can increase the risk of adult metabolic disorders like type 2 diabetes, and examines the role of the antioxidant N-acetyl-l-cysteine (NAC) given during pregnancy and lactation.
- - Researchers treated pregnant and nursing C57bl6/J mice with NAC, then fed their offspring a high-fat diet (HFD) starting at six weeks old.
- - Results showed that NAC-treated offspring had better glucose tolerance, improved insulin sensitivity, and more effective insulin secretion compared to those who only consumed the HFD, suggesting that early-life NAC consumption positively impacts metabolic health in adulthood.
Article Abstract
Exposure to certain environmental factors during the early stages of development was found to affect health in adulthood. Among other environmental factors, oxidative stress has been suggested to be involved in fetal programming, leading to elevated risk for metabolic disorders, including type 2 diabetes; however, the possibility that antioxidant consumption during early life may affect the development of diabetes has scarcely been studied. The aim of this study was to investigate the effects of -acetyl-l-cysteine (NAC) given during pregnancy and lactation on the susceptibility of offspring to develop glucose intolerance at adulthood. C57bl6/J mice were given NAC during pregnancy and lactation. High fat diet (HFD) was given to offspring at an age of 6 weeks for an additional 9 weeks, till the end of the study. Isolated islets of NAC-treated offspring (6 weeks old, before HFD feeding) had an increased efficacy of glucose-stimulated insulin secretion and a higher resistance to oxidative damage. Following HFD feeding, glucose tolerance and insulin sensitivity of NAC-treated offspring were improved. In addition, islet diameter was lower in male offspring of NAC-treated mice compared to their HFD-fed littermates. NAC consumption during early life improves glucose tolerance in adulthood in mice.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139991 | PMC |
| http://dx.doi.org/10.3390/ijms21061981 | DOI Listing |
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