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Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia. | LitMetric

AI Article Synopsis

  • Recent studies have highlighted the significance of long non-coding RNAs (lncRNAs) in the development of leukemia, suggesting their potential use as biomarkers for diagnosis and prognosis in childhood acute lymphoblastic leukemia (ALL).
  • A microarray analysis focused on children with B-lineage ALL found that high expression of lncRNAs LINC00152 and LINC01013 was linked to increased risks of early relapse and mortality, with specific hazard ratios calculated for different expression levels.
  • The findings suggest that LINC00152 might play a regulatory role in certain biological processes related to cell adhesion and could serve as a promising biomarker for predicting relapse in children suffering from B-ALL.

Article Abstract

Evidence showing the role of long non-coding RNAs (lncRNAs) in leukemogenesis have emerged in the last decade. It has been proposed that these genes can be used as diagnosis and/or prognosis biomarkers in childhood acute lymphoblastic leukemia (ALL). To know if lncRNAs are associated with early relapse and early mortality, a microarray-based gene expression analysis in children with B-lineage ALL (B-ALL) was conducted. Cox regression analyses were performed. Hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated. LINC00152 and LINC01013 were among the most differentially expressed genes in patients with early relapse and early mortality. For high expression, the risks of relapse and death were HR: 4.16 (95% CI: 1.46-11.86) and HR: 1.99 (95% CI: 0.66-6.02), respectively; for low expression, the risks of relapse and death were HR: 3.03 (95% CI: 1.14-8.05) and HR: 6.87 (95% CI: 1.50-31.48), respectively. These results were adjusted by NCI risk criteria and chemotherapy regimen. The lncRNA-mRNA co-expression analysis showed that LINC00152 potentially regulates genes involved in cell substrate adhesion and peptidyl-tyrosine autophosphorylation biological processes. The results of the present study point out that LINC00152 could be a potential biomarker of relapse in children with B-ALL.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140896PMC
http://dx.doi.org/10.3390/genes11030302DOI Listing

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