AI Article Synopsis
- - The study investigates the connection between variations in the olfactory bulb and the diversity of progenitor cells in the subventricular zone (SVZ), which contribute to its development.
- - By using modified StarTrack genetic tracing techniques, researchers focused on E12 mice embryos to track the fate of neural progenitors that migrate to the olfactory bulb in adults.
- - The research highlights the distribution and diversity of interneurons in the olfactory bulb, examining their origins, differences, and genetic characteristics linked to specific SVZ progenitor cells.
Article Abstract
The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their molecular profiles remain unknown. Using modified StarTrack genetic tracing strategies, specific SVZ progenitor cells were targeted in E12 mice embryos, and the cell fate of these neural progenitors was determined in the adult olfactory bulb. This study defined the distribution and the phenotypic diversity of olfactory bulb interneurons from specific SVZ-progenitor cells, focusing on their spatial pallial origin, heterogeneity, and genetic profile.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140809 | PMC |
| http://dx.doi.org/10.3390/genes11030305 | DOI Listing |
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