Tidal variations of background ionizing radiation and circadian timing of the suprachiasmatic nucleus clock.

Med Hypotheses

Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences", 660036 Krasnoyarsk, Russia; Siberian Federal University, 660041 Krasnoyarsk, Russia. Electronic address:

Published: March 2020

Recently, correlations of different physiological processes in humans with variations in the local lunisolar gravitational tide force have been observed under highly controlled laboratory conditions. Understanding of the physical nature of this phenomenon needs a comprehensive study of its possible molecular mechanisms. One of the possible timing cues is the strong periodic variation of the emanation fields of radon-222 and its progeny produced by tidal deformations of geological environment. In the present work, we argue that this variation could induce temporal modulation of radiation-induced bystander signaling pathways associated with fundamental regulators of gene expression in the suprachiasmatic nucleus clock.

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http://dx.doi.org/10.1016/j.mehy.2020.109667DOI Listing

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