Background: Dento-skeletal deformities are treated combining orthodontic treatment with orthognathic surgery. One of the techniques most used in this type of surgery is the sagittal osteotomy of the mandible. This technique offers many advantages, but within its disadvantages is the inferior alveolar nerve paresthesia. There are various treatments that aim to recovery of the nerve bundle, and one of them is low intensity laser treatment. The aim of this study was to evaluate the effectiveness of low intensity laser therapy in the recovery of neurosensorial tissues after mandibular sagittal osteotomy during orthognathic surgery.
Methods: Twelve patients submitted to surgery, using mandibular sagittal osteotomy, were treated unilaterally with low intensity infrared (808 nm, GaAIAs active medium) laser, following the inferior alveolar nerve path. The other part of the mandible was treated by placebo. The parameters used were 100 mW of power, irradiancy of 3.6 W/cm2, 2.8J energy per point, an energy density of 100 J/cm2, 28 seconds at each point with a distance of 1.0 cm between points, two sessions per week with a minimum of 10 sessions, starting 48 hours after surgery. Mechanical evaluation was performed in first, fourth, seventh and tenth session.
Results: Significant improvement on the treated side was observed. Comparing the behavior among the variables between the treatment (T) group and the control (C) group in the General Recovery was showed a tendency to better results in the T group when compared to the C group, with statistical difference (P≤0.05) after the 10th laser therapy session.
Conclusions: The treatment of neurosensorial disorders with infrared low intensity laser could be effective in accelerating recovery, providing greater comfort to the patient, and it presents advantages over other existing methods.
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http://dx.doi.org/10.23736/S0026-4970.20.04289-2 | DOI Listing |
To assess whether spinal manipulative therapy (SMT) application procedures (ie, target, thrust, and region) impacted changes in pain and disability for adults with spine pain. Systematic review with network meta-analysis. We searched PubMed and Epistemonikos for systematic reviews indexed up to February 2022 and conducted a systematic search of 5 databases (MEDLINE, EMBASE, CENTRAL [Cochrane Central Register of Controlled Trials], PEDro [Physiotherapy Evidence Database], and Index to Chiropractic Literature) from January 1, 2018, to September 12, 2023.
View Article and Find Full Text PDFJ Neurophysiol
January 2025
Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, Korea.
Previous studies have shown that high-gamma (HG) activity in the primary visual cortex (V1) has distinct higher (broadband) and lower (narrowband) components with different functions and origins. However, it is unclear whether a similar segregation exists in the primary somatosensory cortex (S1), and the origins and roles of HG activity in S1 remain unknown. Here, we investigate the functional roles and origins of HG activity in S1 during tactile stimulation in humans and a rat model.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Genome-wide identification of binding profiles for DNA-binding proteins from the limited number of intracellular pathogens in infection studies is crucial for understanding virulence and cellular processes but remains challenging, as the current ChIP-exo is designed for high-input bacterial cells (>1010). Here, we developed an optimized ChIP-mini method, a low-input ChIP-exo utilizing a 5,000-fold reduced number of initial bacterial cells and an analysis pipeline, to identify genome-wide binding dynamics of DNA-binding proteins in host-infected pathogens. Applying ChIP-mini to intracellular Salmonella Typhimurium, we identified 642 and 1,837 binding sites of H-NS and RpoD, respectively, elucidating changes in their binding position and binding intensity during infection.
View Article and Find Full Text PDFJ Biomed Opt
January 2025
The Johns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, United States.
Significance: Laparoscopic surgery presents challenges in localizing oncological margins due to poor contrast between healthy and malignant tissues. Optical properties can uniquely identify various tissue types and disease states with high sensitivity and specificity, making it a promising tool for surgical guidance. Although spatial frequency domain imaging (SFDI) effectively measures quantitative optical properties, its deployment in laparoscopy is challenging due to the constrained imaging environment.
View Article and Find Full Text PDFChem Sci
January 2025
School of Chemistry and Materials Science, Jiangsu Normal University Xuzhou 221116 China
Reactive oxygen species (ROS) play a critical role in regulating various physiological processes. To gain a comprehensive understanding of their distinct functions in different physiological events, it is imperative to detect binary ROS simultaneously. However, the development of the sensing method capable of binary ROS detection remains a significant challenge.
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