AI Article Synopsis
- The study investigates the use of non-heating extremely low frequency magnetic fields (ELF MF) to manipulate magnetic nanoparticles (MNPs) for pharmaceutical and medical applications.
- The effects of ELF MF on the activity and release of the enzyme superoxide dismutase 1 (SOD1) immobilized on MNPs are analyzed, revealing changes in catalytic activity and enzyme release after exposure.
- Results show a peak effect at a frequency of 50 Hz, suggesting that ELF MF can effectively disrupt the structure of polyion complexes in bionanomaterials without causing significant heating.
Article Abstract
Remote nano-magneto-mechanical actuation of magnetic nanoparticles (MNPs) by non-heating extremely low frequency magnetic field (ELF MF) is explored as a tool for non-invasive modification of bionanomaterials in pharmaceutical and medical applications. Here we study the effects of ELF MF (30-160 Hz, 8-120 kA/m) on the activity and release of a model enzyme, superoxide dismutase 1 (SOD1) immobilized by polyion coupling on dispersed MNPs aggregates coated with poly(L-lysine)-block-poly(ethylene glycol) block copolymer (s-MNPs). Such fields do not cause any considerable heating of MNPs but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations in adjacent materials. We observed the changes in the catalytic activity of immobilized SOD1 as well as its release from the s-MNPs/SOD1 polyion complex upon application of the ELF MF for 5 to 15 min. At longer exposures (25 min) the s-MNPs/SOD1 dispersion destabilizes. The bell-shaped effect of the field frequency with maximum at f = 50 Hz and saturation effect of field strength (between 30 kA/m and 120 kA/m at f = 50 Hz) are reported and explained. The findings are significant as one early indication of the nano-magneto-mechanical disruption by ELF MF of cooperative polyion complexes that are widely used for design of current functional healthcare bionanomaterials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076007 | PMC |
| http://dx.doi.org/10.1038/s41598-020-61364-w | DOI Listing |
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