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Targeting complex, adaptive responses in melanoma therapy. | LitMetric

Targeting complex, adaptive responses in melanoma therapy.

Cancer Treat Rev

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

Published: June 2020

Our understanding of the complex, adaptive mechanisms of response to targeted therapies in metastatic melanoma is now leading to more effective combination treatments. These include the simultaneous inhibition of signalling pathways and metabolic programmes, as well as epigenetic mechanisms or immunological checkpoints. We review the latest pre-clinical and clinical results of strategies to delay tumor progression through combination approaches, and also highlight some of the problems ahead, including patient stratification, the complexity of targeting adaptive responses, and the management of more severe toxicities that result from double and triple-drug treatments.

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Source
http://dx.doi.org/10.1016/j.ctrv.2020.101997DOI Listing

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