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Background: Developing interventions along with the population of interest using systems thinking is a promising method to address the underlying system dynamics of overweight. The purpose of this study is twofold: to gain insight into the perspectives of adolescents regarding: (1) the system dynamics of energy balance-related behaviours (EBRBs) (physical activity, screen use, sleep behaviour and dietary behaviour); and (2) underlying mechanisms and overarching drivers of unhealthy EBRBs.

Methods: We conducted Participatory Action Research (PAR) to map the system dynamics of EBRBs together with adolescents aged 10-14 years old living in a lower socioeconomic, ethnically diverse neighbourhood in Amsterdam East, the Netherlands.

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The Jordan Valley (JV) is a critical region where the interplay of water, energy, food, and ecosystem (WEFE) dynamics presents both challenges and opportunities for sustainable development and climate change mitigation and adaptation. In such a transboundary river basin with acute nexus problems and a long history of conflicts, it is essential that conscious efforts are made to pluralize the debate and actively encourage stakeholders' empowerment, participation and fair collaboration in strategic planning. An integrated framework for participatory strategic planning in the WEFE nexus is proposed, which has been developed in the context of the JV case study.

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A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection.

Viruses

January 2025

Department of Microbiology and Immunology, Miller School of Medicine, University of Miami/UHealth, Miami, FL 33136, USA.

Flaviviruses are a diverse group of viruses primarily transmitted through hematophagous insects like mosquitoes and ticks. Significant expansion in the geographic range, prevalence, and vectors of flavivirus over the last 50 years has led to a dramatic increase in infections that can manifest as hemorrhagic fever or encephalitis, leading to prolonged morbidity and mortality. Millions of infections every year pose a serious threat to worldwide public health, encouraging scientists to develop a better understanding of the pathophysiology and immune evasion mechanisms of these viruses for vaccine development and antiviral therapy.

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The aging population poses a significant challenge to global public health, impacting the physical, mental, and social health of older adults. Social activity has been widely acknowledged as a protective factor for both mental and physical well-being. Research indicates that consistent engagement in social activities can mitigate the risk of depression, prevent cognitive decline, and support physical functionality.

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Cell-to-Cell Natural Transformation Mediated Efficient Plasmid Transfer Between Species.

Int J Mol Sci

January 2025

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.

Horizontal gene transfer (HGT) plays a pivotal role in bacterial evolution, shaping the genetic diversity of bacterial populations. It can occur through mechanisms such as conjugation, transduction, and natural transformation. , a model Gram-positive bacterium, serves not only as a robust system for studying HGT but also as a versatile organism with established industrial applications, such as producing industrial enzymes, antibiotics, and essential metabolites.

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