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Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.
Front Endocrinol (Lausanne)
January 2025
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Background: Evidence indicates a negative link between glucosamine and age-related cognitive decline and sarcopenia. However, the causal relationship remains uncertain. This study aims to verify whether glucosamine is causally associated with cognitive function and sarcopenia.
View Article and Find Full Text PDFNanoparticles for the Delivery of Pro-regenerative Cardiac Progenitor Secretory Proteins Targeting Cellular Senescence and Vasculogenesis.
ACS Appl Bio Mater
January 2025
Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3E2, Canada.
Contemporary therapies following heart failure center on regenerative approaches to account for the loss of cardiomyocytes and limited regenerative capacity of the adult heart. While the delivery of cardiac progenitor cells has been shown to improve cardiac function and repair following injury, recent evidence has suggested that their paracrine effects (or secretome) provides a significant contribution towards modulating regeneration, rather than the progenitor cells intrinsically. The direct delivery of secretory biomolecules, however, remains a challenge due to their lack of stability and tissue retention, limiting their prolonged therapeutic efficacy.
View Article and Find Full Text PDFEffect of Electroacupuncture Treatment on Bladder Function and Urodynamic Features of Neurogenic Bladder in Stroke: A Retrospective Study.
Arch Esp Urol
December 2024
Department of Urology, Jinggangshan University Affiliated Hospital, 343000 Ji'an, Jiangxi, China.
Background: Neurogenic bladder dysfunction is a common consequence of stroke, and it substantially impacts the quality of life and functional independence of affected individuals. Traditional treatment modalities have limitations in achieving optimal outcomes. This study aims to explore the effects of electroacupuncture treatment on bladder function and neurogenic bladder urodynamic characteristics in stroke patients.
View Article and Find Full Text PDFConstruction of carbon dot-embedded fluorescent hydrogels based on oxidized gum arabic-gelatin Schiff base for Cr(VI) detection applications.
Int J Biol Macromol
January 2025
School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China. Electronic address:
In this study, a novel nitrogen-doped carbon quantum dot/oxidized gum arabic-gelatin-based fluorescent probe (NAH) was prepared using gelatin (GL) and gum arabic (AG) biomolecules. The primary network structure of this hydrogel consisted of polyacrylamide (PAM), while a secondary network structure was constructed between oxidized gum arabic and gelatin through the reaction of the Schiff base, which significantly enhanced the mechanical properties, the stress and strain of NAH reached 266.47 KPa and 2175.
View Article and Find Full Text PDFHip Fracture Intervention Study for Prevention of Hypotension Trial: a Pilot Randomized Controlled Trial.
A A Pract
January 2025
Anaesthesia and Critical Care Section, Academic Unit of Injury, Inflammation and Repair, University of Nottingham, Nottingham, UK.
Background: Hypotension during anesthesia for surgery for hip fracture is common and associated with myocardial injury, stroke, acute kidney injury, and delirium. We hypothesized that maintaining intraoperative blood pressure close to patients' preoperative values would reduce these complications compared to usual care.
Methods: A pilot feasibility patient- and assessor-blinded parallel group randomized controlled trial.
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