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An experimental chimeric hepatitis E virus vaccine elicits both local and systemic immune responses.
Front Microbiol
December 2024
Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONI-CET-UNT, Tucumán, Argentina.
Introduction: The development of a hepatitis E virus (HEV) vaccine is critical, with ORF2 capsid protein as the main target. We previously demonstrated that oral coadministration of recombinant ORF2 with immunomodulatory bacterium-like-particles (IBLP) induces a specific immune response in mice, particularly using IBLP derived from IBL027 (IBLP027), which was effective in eliciting a local humoral response. IBLP are non-live bacteria with adjuvant and carrier properties, serving as a platform for exposing proteins or antigens fused to LysM (lysine motif) domains, protein modules that bind to cell wall polysaccharides like peptidoglycan.
View Article and Find Full Text PDFLessons learned from the COVID-19 pandemic: identifying hesitant groups and exploring reasons for vaccination hesitancy, from adolescence to late adulthood.
Front Public Health
January 2025
Department of Social Sciences, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Introduction: The COVID-19 (COronaVIrus Disease-2019) pandemic highlighted the importance of assessing the rationales behind vaccine hesitancy for the containment of pandemics. In this nationwide study, representative of the Luxembourgish population, we identified hesitant groups from adolescence to late adulthood and explored motivations both for and against vaccination.
Methods: We combined data collected via online surveys for the CON-VINCE (COvid-19 National survey for assessing VIral spread by Non-affected CarriErs) study, 1865 respondents aged 18-84, and for the YAC (Young people And Covid-19) study, 3740 respondents aged 12-29.
Identification, classification, and documentation of drug related problems in community pharmacy practice in Europe: a scoping review.
Int J Clin Pharm
January 2025
Department of Clinical Pharmacy, Leopold-Franzens Universität, Innsbruck, Austria.
Background: Drug-related problems (DRPs) are significant issues in healthcare contributing to adverse health outcomes and increased healthcare costs. While community pharmacists play a pivotal role in identifying, classifying, and documenting DRPs, there is a need to map approaches undertaken.
Aim: The aim of this scoping review was to examine the approaches to identifying, classifying, and documenting DRPs in community pharmacies in Europe, and their associated barriers and facilitators.
Overcoming Challenges in Cancer Care: A Focus on Emerging Technologies.
Biomedicines
December 2024
Hirotsu Bioscience Inc., New Otani Garden Court 22F, 4-1 Kioi-cho, Chiyoda-ku, Tokyo 102-0094, Japan.
Cancer research is rapidly evolving, propelled by advancements in molecular biology, genomics, and immunology [...
View Article and Find Full Text PDFHierarchy in surgeon-anaesthetist relationships.
Br J Anaesth
January 2025
Centre for Medical and Health Sciences Education, School of Medicine, University of Auckland, Auckland, New Zealand; Auckland City Hospital Department of Anaesthesia and Perioperative Medicine, Auckland, New Zealand; Australian and New Zealand College of Anaesthetists, Melbourne, VIC, Australia. Electronic address:
Operating theatres are steeply hierarchical, and yet the hierarchy between surgeons and anaesthetists is unclear, even blurry. Both the steep hierarchy and the blurriness at the top can present a risk to patient safety through inhibiting speaking up with concerns and negotiating safe patient care. A recent study in the British Journal of Anaesthesia explores hierarchy in the surgeon-anaesthesia dyad in China, in particular, the effect of increased seniority gap between surgeons and anaesthetists on anaesthesia-related adverse outcomes.
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