The aim of this study was to analyze the accumulation of nonylphenols (NPs) and nonylphenol ethoxylates (NPEOs) in the muscles, liver, and bile of flounder (Platichthys flesus), cod (Gadus morhua), and eels (Anguilla anguilla). The flounder and cod were caught in the Gulf of Gdańsk (the Baltic Sea), while the eels were sampled in the Vistula and Szczecin lagoons (the Baltic Sea) and in the inland waters of the Masurian Lake District. NP concentrations in muscles were low in all the samples analyzed and ranged from 14.2 to 28.2 μg-1 kg ww. In contrast, a wide range of NP concentrations were observed in livers, which seemed to depend on both the species and the feeding status of the fishes. NP levels in flounder and eel livers were from three to twenty times higher than those in the muscles, but they were below the limit of quantitation (LOQ) in all the cod liver samples. The mean concentration of NPs in the liver of flounder caught in the Gulf of Gdańsk was 222 μg kg-1 ww, while in that of the eel ranged from 57 μg kg-1 ww in fish caught in the Masurian Lake District to 519 μg kg-1 ww in eels caught in the Vistula Lagoon. NPs were detected in bile in only a few eel samples, which indicated that bile analysis has limited applications for estimating NP contamination in marine fish. The NPEOs in all the samples analyzed were below the LOQ.
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http://dx.doi.org/10.1039/c9em00584f | DOI Listing |
Acta Neurochir Suppl
October 2019
Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Background: Subarachnoid hemorrhage (SAH) is a severe and emergent cerebrovascular disease, the prognosis of which usually very poor. Microthrombi formation highlighted with inflammation occurs early after SAH. As the main cause of DCI, microthrombosis associated with the prognosis of SAH.
View Article and Find Full Text PDFMacromol Biosci
January 2017
Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI, 53705, USA.
Triolimus is a multi-drug loaded polymeric micelle containing paclitaxel (PTX), 17-allylamino-17-demethoxygeldanamycin (17-AAG), and rapamycin (RAP). This study examines the radiosensitizing effect of Triolimus in vitro and in vivo. Radiosensitizing effects of Triolimus on A549 cells are dose dependent and at 2 × 10 m, Triolimus shows significant radiosensitization even at low radiation doses (2 Gy).
View Article and Find Full Text PDFXenobiotica
March 2017
a Epizyme Inc , Cambridge , MA , USA and.
1. The plasma clearance of the first-in-class DOT1L inhibitor, EPZ-5676 (pinometostat), was shown to be markedly lower in human compared to the preclinical species, mouse, rat and dog. 2.
View Article and Find Full Text PDFAims: The primary aim of this study was to describe the pharmacokinetics of total and unbound bupivacaine and ropivacaine following epidural bolus and infusion in neonates and young infants. Secondary aims were to investigate the influence of alpha-1-acid glycoprotein (AAG) on the concentration-time profiles and to determine the efficacy and adverse event profile of the epidural regimen.
Methods/materials: Thirty-one infants aged 40-63 weeks of postmenstrual age (PMA) undergoing hernia repair or abdominal surgery received an epidural injection of 1.
Paediatr Anaesth
September 2004
Department of Anaesthesiology, Universitätsklinikum Mannheim, Mannheim, Germany.
Background: The aims of this study were to evaluate pharmacokinetics, efficacy and safety of ropivacaine in infants aged 0-12 months following a single caudal injection.
Methods: Term ASA I-III patients, scheduled for surgery, with a body weight of > or = 2500 g received a caudal block with ropivacaine 2 mg x ml(-1), 1.0 ml x kg(-1).
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