Bioinspired Dual-Responsive Nanofluidic Diodes by Poly-l-lysine Modification.

A smart nanofluidic device attracts attention as it enables to control the physicochemical properties and transportation phenomena, by using stimuli-responsive materials. This work reports a bioinspired modification of a conical ion track-etched polyethylene terephthalate nanopore surface by coating a layer of poly-l-lysine (PLL), which is a commonly used coating in biotechnology to achieve a dual-responsive nanofluidic channel by pH or temperature. The rectification of ionic transportation can be reversed by assembling PLL because of the change of surface bonds from the carboxyl to amine group. The PLL-modified nanopore becomes nonconductive as an "OFF" state at pH 11.5 and at a temperature of 70 °C in solution. The ionic transport in nanopores can be switched to the "ON" (conductive) state, by either decreasing pH or temperature. The transitions between "ON" and "OFF" states present excellent reversibility, which make the PLL-modified nanopores a promising smart nanofluidic device that can be used for drug delivery or biomimic ion/mass transport in future, besides the good biocompatibility and ease of use of PLL modification.