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Analysis of cardiac developmental toxicity induced by m-cresol in early life of zebrafish and its mechanism.
Comp Biochem Physiol C Toxicol Pharmacol
January 2025
Center for Clinical Medicine Research, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China. Electronic address:
The compound m-Cresol, also referred to as 3-methylphenol,acts as a precursor in the creation of pesticides and plasticizers. This research has conducted a thorough evaluation of the toxic effects of m-cresol on the cardiac development of juvenile zebrafish, from 6 to 72 hpf. The study's results reveal that higher concentrations of m-Cresol, compared to lower ones, result in more severe heart abnormalities in zebrafish larvae.
View Article and Find Full Text PDFInterpretation and management of T wave inversion in athletes: AnKazimexpert opinion statement of the Italian Society of Sports Cardiology (SICSPORT).
Int J Cardiol
January 2025
Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padova, Italy. Electronic address:
Article Synopsis
- T wave inversion (TWI) on ECG is common in athletes and can signal either harmless changes or serious heart issues, requiring careful interpretation.
- Understanding TWI involves considering its location, associated symptoms, and patient demographics, which help differentiate between physiological adaptations and pathological conditions.
- The management of athletes with TWI includes thorough diagnostic evaluations, follow-ups, and careful considerations regarding sports participation to prioritize athlete safety without excessive restrictions.
The growing range of complications of diabetes mellitus.
Trends Endocrinol Metab
January 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
With the rising prevalence of type 2 diabetes mellitus (T2DM) and obesity, several previously under-recognised complications associated with T2DM are becoming more evident. The most common of these emerging complications are metabolic dysfunction-associated steatotic liver disease (MASLD), cancer, dementia, sarcopenia, and frailty, as well as other conditions involving the lung, heart, and intestinal tract. Likely causative factors are chronic inflammation and insulin resistance, whereas blood glucose levels appear to play a lesser role.
View Article and Find Full Text PDFA novel technique for heart-thymus en bloc transplantation in nonhuman primates.
Sci Rep
December 2024
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA.
The thymus is a rich source of regulatory T cells and plays a role in self-tolerance. Therefore, transplantation of a vascularized donor thymus may facilitate the induction of tolerance in recipients of a cotransplanted heart allograft. To investigate this hypothesis, we developed a new technique to procure the heart and thymus en bloc from juvenile donors and transplant the composite allograft into thymectomized recipients.
View Article and Find Full Text PDFLung transplantation for diffuse pulmonary arteriovenous malformations associated with juvenile polyposis-hereditary hemorrhagic telangiectasia overlap syndrome: a case report.
Gen Thorac Cardiovasc Surg Cases
December 2024
Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Background: Lung transplantation is a viable lifesaving option for patients with diffuse pulmonary arteriovenous malformations (AVMs). We present a case of diffuse pulmonary AVMs associated with juvenile polyposis and hereditary hemorrhagic telangiectasia (JP-HHT) that was successfully managed by lung transplantation.
Case Presentation: A 19-year-old woman developed severe hypoxemia due to pulmonary AVMs diagnosed at 4 years of age.
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