Investigators from the Mayo Clinic, Rochester, MN, evaluated 157 patients with confirmed myopathy who had electrodiagnostic studies done between January 2007 and May 2017.
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http://dx.doi.org/10.15844/pedneurbriefs-34-4 | DOI Listing |
Sci Rep
January 2025
Department of Sport Biomechanics, Faculty of Sports Sciences, Bu-Ali Sina University, Hamedan, Iran.
Most sports and leisure activities involve repetitive movements in the upper limb, which are typically linked to pain and discomfort in the neck and shoulder area. Movement variability is generally expressed by changes in movement parameters from one movement to another and is a time-dependent feature of repetitive activities. The purpose of this study was to examine the effect of repeated movement-induced fatigue on biomechanical coordination and variability in athletes with and without chronic shoulder pain (CSP).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
VA Boston Healthcare System, Boston, MA, USA.
Background: T-cell infiltration into the brain parenchyma is associated with hyperphosphorylated tau (p-tau) accumulation in neurodegenerative diseases. Chronic traumatic encephalopathy (CTE) is a progressive tauopathy caused by exposure to repetitive head impacts (RHI). CTE is defined by the perivascular accumulation of p-tau at the cortical sulcal depths and can be stratified into mild and severe pathological stages.
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December 2024
Harvard University School of Medicine, Cambridge, MA, USA.
Background: Exposure to repetitive head impacts (RHI) is associated with the neurodegenerative tauopathy chronic traumatic encephalopathy (CTE). There is substantial heterogeneity in the clinical presentation of CTE. Younger age of first exposure (AFE) to American football has not been associated with odds or severity of CTE.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.
Background: Automated analysis of natural speech is emerging as a promising digital biomarker of Alzheimer's disease (AD). As speech is a complex process, relying on multiple interacting cognitive functions, fine-grained analysis of speech may have the potential to capture subtle cognitive deficits in the very early stages of AD. Here, we examined the association between amyloid-beta (Aβ) pathology and acoustic speech characteristics in a group of cognitively normal Dutch adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Boston University Alzheimer's Disease Research Center, Boston, MA, USA.
Background: Traumatic encephalopathy syndrome (TES) is the proposed clinical syndrome of chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repetitive head impacts in contact/collision sports. A core clinical feature of TES is cognitive impairment, particularly in memory and executive functions. Cognitive intraindividual variability (IIV) is the extent of variability in neuropsychological test performance (i.
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