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Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation.
Cell Rep
December 2024
Institut de Biologie de l'ENS (IBENS), CNRS, INSERM, Ecole Normale Supérieure, PSL Research University, Paris, France. Electronic address:
Multiciliated cells (MCCs) ensure fluid circulation in various organs. Their differentiation is marked by the amplification of cilia-nucleating centrioles, driven by a genuine cell-cycle variant, which is characterized by wave-like expression of canonical and non-canonical cyclins such as Cyclin O (CCNO). Patients with CCNO mutations exhibit a subtype of primary ciliary dyskinesia called reduced generation of motile cilia (RGMC).
View Article and Find Full Text PDFWeb-Based Parent Training With Telephone Coaching Aimed at Treating Child Disruptive Behaviors in a Clinical Setting During the COVID-19 Pandemic: Single-Group Study With 2-Year Follow-Up.
JMIR Pediatr Parent
December 2024
Research Centre for Child Psychiatry, University of Turku, Turku, Finland.
Background: There is a lack of studies examining the long-term outcomes of web-based parent training programs implemented in clinical settings during the COVID-19 pandemic.
Objective: The aim is to study 2-year outcomes of families with 3- to 8-year-old children referred from family counseling centers to the Finnish Strongest Families Smart Website (SFSW), which provides digital parent training with telephone coaching aimed at treating child disruptive behaviors.
Methods: Counseling centers in Helsinki identified fifty 3- to 8-year-old children with high levels of disruptive behavioral problems.
Self-Management assistance for recommended treatment (SMART) IBD app randomized control trial in adolescents with IBD: Design and methodology.
Health Care Transit
November 2023
Cincinnati Children's Hospital Medical Center, Center for Health Technology Research, Division of Behavioral Medicine and Clinical Psychology, USA.
Aims: Adherence to medical regimens, including medications and appointments, is a significant concern for adolescent populations that warrants behavioral interventions. Negative health behaviors during adolescence can persist into adulthood and lead to long-term negative health outcomes. Due to the limited availability and resources for behavioral self-management intervention, many youth do not receive evidence-based behavioral care and continue to struggle with managing their illness.
View Article and Find Full Text PDFTrends in pH-triggered strategies for dental resins aiming to assist in preventing demineralization: A scoping review.
J Dent
December 2024
Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro (UFRJ), Rodolpho Paulo Rocco, 325, Rio de Janeiro, RJ 21941-617, Brazil. Electronic address:
Objectives: To identify and map the literature on the current state of pH-triggered strategies for resin-based materials used in direct restorative dentistry, focusing on innovative compounds, their incorporation and evaluation methods, and the main outcomes.
Data And Sources: Through a search across PubMed, Scopus, Embase, Web of Science, LILACS, Cochrane Library databases, and Google Scholar, this review identified studies pertinent to pH-responsive dental materials, excluding resin-modified glass ionomer cements.
Study Selection: From the 981 records identified, 19 in vitro studies were included, concentrating on resin-based composite resins (50 %), dentin adhesives (25 %), and sealants (25 %).
Development of Multimodal Training Tool for Preterm Infant Care.
Indian J Pediatr
December 2024
Department of Pediatrics, WHO Collaborating Center for Newborn Care and Research, All India Institute of Medical Sciences, New Delhi, 110 029, India.
Objectives: Comprehensive packages for training healthcare professionals who care for premature newborns are scarce. AIIMS WHO CC, New Delhi, partnered with India Association of Neonatal Nurses (IANN) and National Neonatology Forum (NNF) and 35 national leaders in the field of newborn care to develop a multimodal educational package for preterm infants.
Methods: Findings from evaluation of four representative special newborn care units in the state of Madhya Pradesh informed the content of the package.
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