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Comparative and Functional Analysis of Exosomal microRNAs During Semelparous Reproduction in Ayu Fish ().
J Extracell Biol
March 2025
Department of Aquatic Bioscience, Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and Life Sciences The University of Tokyo Bunkyo Tokyo Japan.
As a life history strategy, some semelparous organisms, such as the ayu fish (), reproduce only once in their lifetime and then die. They invest heavily in their single reproductive event, producing many offspring. However, the regulatory mechanisms that trigger mortality after reproduction are not well understood.
View Article and Find Full Text PDFFactorial Mendelian randomization of lipoprotein (a) lowering, low-density lipoprotein cholesterol lowering, and lifestyle improvements: joint associations with cardiovascular risk.
Int J Epidemiol
February 2025
The Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Background: High levels of lipoprotein(a) [Lp(a)] have been associated with an increased risk of cardiovascular disease (CVD); however, the effects of Lp(a)-lowering therapy in combination with low-density lipoprotein cholesterol (LDL-C)-lowering treatment or lifestyle improvements on CVD risk remain unexplored.
Methods: We conducted a factorial Mendelian randomization study among 385 917 participants in the UK Biobank. Separate genetic scores were constructed to proxy the effects of Lp(a) lowering, LDL-C lowering through different targets [HMG-CoA reductase, NPC1-like intracellular cholesterol transporter 1, proprotein convertase subtilisin/kexin Type 9, and low-density lipoprotein receptor (LDLR)], as well as improvements in body mass index (BMI), systolic blood pressure (SBP), and lifestyle factors (cigarette smoking, alcohol consumption, and physical activity).
Mechanisms of developmental neurotoxicity mediated by perturbed thyroid hormone homeostasis in the brain: an adverse outcome pathway network.
Crit Rev Toxicol
March 2025
Centre for Health Protection (GZB), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Thyroid hormone (TH) is crucial for proper neurodevelopment. Insufficient TH concentrations in early life are associated with lower IQ and delayed motor development in children. Intracellular levels of TH are modulated via the transmembrane transport of TH and intracellular deiodination, and can mediate gene transcription via binding to the nuclear TH receptor.
View Article and Find Full Text PDFAnisotropy, topography and non-newtonian properties of cellular interiors probed by helical magnetic nanobots.
J Microbio Robot
March 2025
Department of Physics, Indian Institute Of Science, Bangalore, 560012 Karnataka India.
Unlabelled: Cells are building blocks of living systems. Spatio-temporal mapping of local biophysical changes within cells can lead to novel insights into various biological events. As demonstrated in previous works, successful internalization, controlled manipulation, bio-compatibility, and surface-functionalization capabilities make the helical magnetic nanobots, an ideal candidate for local intracellular measurements.
View Article and Find Full Text PDFGenome-wide identification and expression profile analysis of TALE superfamily genes under hormone and abiotic stress in maize ( L.).
Front Plant Sci
February 2025
Department of Food Testing, Binzhou Testing Center, Binzhou, Shandong, China.
Introduction: The three-amino-acid-loop-extension (TALE) of the homeobox superfamily genes plays important roles in plant growth, development, and responses to environmental stress. Although TALE members have been identified in various species, they have not been systematically characterized in maize and their expression profiles under ABA hormone and abiotic stress are unknown.
Methods: Bioinformatics methods were employed to identify the TALE family genes in the maize genome.
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