Successful treatment of metastatic colorectal cancer with synchronous mutation and dMMR with BGB-A317.

Immunotherapy

Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.

Published: March 2020

AI Article Synopsis

  • Metastatic colorectal cancer with mutations is aggressive, has a poor outlook, and limited treatment options.
  • The case involved a patient with a specific mutation and DNA mismatch-repair deficiency who faced postoperative recurrence and metastasis.
  • Treatment with a new anti-PD-1 antibody called BGB-A317 led to continuous improvement in the patient's condition.

Article Abstract

Metastatic colorectal cancer with mutation is a type of highly invasive malignant tumor with poor prognosis and few treatment options. Here, we report a case of a -mutant and DNA mismatch-repair deficiency colorectal cancer patient with postoperative recurrence as well as abdominal cavity and pelvic metastasis, whose condition was relieved continuously after treatment with a new anti-PD-1 antibody, BGB-A317.

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Source
http://dx.doi.org/10.2217/imt-2019-0148DOI Listing

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