AI Article Synopsis
- cAMP and cGMP are important molecules that help regulate heart function, and their levels are controlled by enzymes called phosphodiesterases (PDEs).
- In heart failure (HF), changes in the expression and activity of various PDEs disrupt the balance of these cyclic nucleotides, leading to heart dysfunction.
- The text reviews the roles of different PDEs in heart health, explores research on how altered PDE signaling contributes to HF, and discusses the potential for new treatments targeting these enzymes.
Article Abstract
The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) maintain physiological cardiac contractility and integrity. Cyclic nucleotide-hydrolysing phosphodiesterases (PDEs) are the prime regulators of cAMP and cGMP signalling in the heart. During heart failure (HF), the expression and activity of multiple PDEs are altered, which disrupt cyclic nucleotide levels and promote cardiac dysfunction. Given that the morbidity and mortality associated with HF are extremely high, novel therapies are urgently needed. Herein, the role of PDEs in HF pathophysiology and their therapeutic potential is reviewed. Attention is given to PDEs 1-5, and other PDEs are briefly considered. After assessing the role of each PDE in cardiac physiology, the evidence from pre-clinical models and patients that altered PDE signalling contributes to the HF phenotype is examined. The potential of pharmacologically harnessing PDEs for therapeutic gain is considered.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242274 | PMC |
| http://dx.doi.org/10.1007/s10557-020-06959-1 | DOI Listing |
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