AI Article Synopsis
- The study introduces a new camera-based system for monitoring and controlling ultra-low dose powder feeding, using caffeine as a test material.
- The videometric system, consisting of a high-speed camera and image analysis software, effectively measures mass, mass flow, and particle sizes in real-time.
- This technology enables automatic adjustments of the feeder speed to maintain desired mass flow rates, enhancing process control in continuous pharmaceutical manufacturing.
Article Abstract
The present paper reports the first monitoring and control of ultra-low dose powder feeding using a camera image-based mass flow measurement system. Caffeine was fed via a single-screw microfeeder as a model active pharmaceutical ingredient (API). The mass, mass flow and sizes of the particles were successfully monitored in real-time by the developed videometric system consisting of a high-speed process camera coupled with an image analysis software. The system was also tested in feedback control mode to automatically reach the desired mass flow values by adjusting the feeder speed based on the mass flow measured by the image analysis system. Based on these features, the developed videometric system can serve as a multi-purpose PAT-tool and can provide valuable real-time information about the process which is indispensable for modern continuous pharmaceutical manufacturing.
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| http://dx.doi.org/10.1016/j.ijpharm.2020.119223 | DOI Listing |
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