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Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls.
Arthritis Res Ther
November 2024
Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Str. Pasteur nr.6, Cluj, Napoca, 400349, Romania.
Article Synopsis
- * Research focused on IL1RN rs9973741, highlighting that this gout risk allele (G) is associated with decreased production of the anti-inflammatory cytokine IL-1Ra after stimulation and increased IL-1β production in immune cells.
- * The findings suggest that the genetic variations in the IL1RN-IL1F10 locus influence how immune cells respond to MSU crystals, contributing to the inflammatory processes involved in gout.
New discoveries in the genetics and genomics of systemic juvenile idiopathic arthritis.
Expert Rev Clin Immunol
September 2024
Division of Rheumatology, Cincinnati Children's Medical Center, Cincinnati, OH, USA.
Introduction: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory condition with onset in childhood. It is sporadic, but elements of its stereotypical innate immune responses are likely genetically encoded by both common variants with small effect sizes and rare variants with larger effects.
Areas Covered: Genomic investigations have defined the unique genetic architecture of sJIA.
Association between (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis.
PeerJ
October 2021
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China.
Interleukin-1 (IL-1) plays an essential role in the immune pro-inflammatory process, which is regarded as one of many factors in the development of type 2 diabetes mellitus (T2DM). Several case-control studies have illustrated the association of the (-511) (rs16944, Chr 2:112,837,290, C/T Intragenic, Transition Substitution) and (VNTR) (gene for IL-1 receptor antagonist, IL-1RA, 86 bp tandem repeats in intron 2) polymorphisms with T2DM risk. However, the results were inconsistent and inconclusive.
View Article and Find Full Text PDFEarly Treatment and IL1RN Single-Nucleotide Polymorphisms Affect Response to Anakinra in Systemic Juvenile Idiopathic Arthritis.
Arthritis Rheumatol
June 2021
Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Objective: To evaluate the impact of early treatment and IL1RN genetic variants on the response to anakinra in systemic juvenile idiopathic arthritis (JIA).
Methods: Response to anakinra was defined as achievement of clinically inactive disease (CID) at 6 months without glucocorticoid treatment. Demographic, clinical, and laboratory characteristics of 56 patients were evaluated in univariate and multivariate analyses as predictors of response to treatment.
The association between IL-1 family gene polymorphisms and colorectal cancer: A meta-analysis.
Gene
February 2021
Library, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:
Background: Colorectal cancer (CRC) is a major public health problem given its high incidence and mortality. This study focuses on examining the associations between IL-1α, IL-1β, and IL-1RN polymorphisms and colorectal cancer susceptibility.
Methods: A systematic literature search of PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure) and Wan Fang databases was conducted to identify relevant studies.
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