C1q/TNF-related protein 1 (CTRP1), a conserved protein of the C1q family, plays a key role in cardiovascular and metabolic diseases. However, the role of CTRP1 in renal injury is unclear. The purpose of this study is to explore the role of CTRP1 in unilateral ureteral obstruction (UUO)-induced renal fibrosis and to elucidate the underlying mechanism. Using gene delivery system, CTRP1 was overexpressed in the kidney, then the mice were operated to induce UUO model after adenovirus transfection. It was found that the expression of CTRP1 in the renal tissue was decreased in mice after UUO. CTRP1 overexpression decreased the kidney function and kidney weight index. Moreover, CTRP1 reduced oxidative stress and renal collagen deposition in vivo. As expected, we found that CTRP1 activated AMP-activated kinase (AMPK) and decreased NOX4 expression, while silencing AMPKα1 abolished the protective effects of CTRP1 overexpression in mice after UUO. In conclusion, CTRP1 may protect against UUO-induced renal injury via AMPK/NOX4 signaling. Our results indicate that CTRP1 exhibits potential effects to treat renal fibrosis caused by UUO.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11596-020-2145-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic Evidence of Causal Effect between C1q/TNF-Related Protein-1 and Atherosclerosis: a Bidirectional and Multivariate Mendelian Randomization Study.
J Atheroscler Thromb
November 2024
Department of Ultrasound Imaging, Renmin Hospital of Wuhan University.
Article Synopsis
- The study investigates the role of C1q/TNF-related protein-1 (CTRP1) in causing atherosclerosis across different blood vessel sites, building on prior links between CTRP1 and coronary artery disease.
- Using data from the FinnGen biobank and Ischemic Stroke cohort, the research employs various statistical methods to establish a reliable causal relationship between CTRP1 and atherosclerosis at cerebral, coronary, and other vascular locations.
- The findings suggest that CTRP1 is significantly involved in atherosclerosis and its potential as a target for prevention and treatment is highlighted, with additional analyses confirming its independent effect despite other confounding factors.
Downregulation of CTRP1 reduces radio-resistance in glioblastoma cells by inhibiting the expression of CD133 after X-ray and carbon ion irradiation.
Exp Cell Res
January 2025
Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, PR China. Electronic address:
Glioblastomas (GBMs), the most prevalent primary malignant brain tumors, present significant challenges due to their invasive nature, high recurrence rates, and limited treatment options. Radiotherapy is a cornerstone in the management of GBMs; however, resistance to treatment poses a substantial obstacle. This study investigates the role of adipokine C1q/TNF-related protein 1 (CTRP1) in the radio-sensitivity of GBMs, utilizing both X-ray and carbon ion irradiation.
View Article and Find Full Text PDFEffect of azilsartan on myocardial remodeling after acute myocardial infarction.
Eur J Clin Pharmacol
February 2024
Department of Cardiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China.
Article Synopsis
- The study investigates how azilsartan affects heart structure changes after a heart attack (AMI) in patients undergoing treatment.
- 200 AMI patients were randomly assigned to receive either azilsartan or benazepril, with their heart function assessed through various tests over a year.
- Results showed that azilsartan led to better heart size and function improvement compared to benazepril, suggesting it could be effective for managing heart changes post-AMI.
Multi-faceted roles of C1q/TNF-related proteins family in atherosclerosis.
Front Immunol
October 2023
College of Life Science and Technology, Xinjiang University, Xinjiang, China.
Purpose Of Review: C1q/TNF-related proteins (CTRPs) are involved in the modulation of the development and prognosis of atherosclerosis (AS). Here, we summarizes the pathophysiological roles of individual members of the CTRP superfamily in the development of AS. Currently, there is no specific efficacious treatment for AS-related diseases, therefore it is urgent to develop novel therapeutic strategies aiming to target key molecules involved in AS.
View Article and Find Full Text PDFThe correlation between two potentially antagonistic human adipocytokines, WISP-1 and CTRP1, and their association with insulin resistance.
Ann Agric Environ Med
September 2023
Department of Public Health, University of Medical Sciences, Poznań, Poland.
Introduction And Objective: Wnt-1 signaling pathway protein 1 (WISP-1) and complement-C1q TNF-related protein 1 (CTRP1) are adipokines with possible opposite effects in regulating insulin sensitivity. The study investigated the correlation between circulating WISP-1 and CTRP1 in non-diabetic patients. Correlations between adipokines concentrations and biochemical and anthropometric parameters were also studied.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!