Two new helvolic acid analogues ( and ) and one new fumagillin derivative containing an octahydroisobenzofuran moiety (), together with four known compounds (-), were isolated from an , isolated from soil collected from Mauna Kea, the highest mountain in Hawaii. Compound was recorded in SciFinder with a CAS Registry Number of 1379525-35-5, but it was not documented in the cited reference (. , , 137). The structures of compounds - were elucidated by NMR spectroscopy and HRMS and ECD analysis. Compounds and showed significant inhibitory activity against NF-κB with IC values of 2.7 ± 2.6 and 6.5 ± 0.8 μM, respectively. Compounds and were active against with MICs of 6.25 and 6.25 μg/mL, respectively, while compound inhibited with an MIC of 3.12 μg/mL.
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| http://dx.doi.org/10.1021/acs.jnatprod.9b01190 | DOI Listing |
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