AI Article Synopsis
- A thermally dimorphic fungus causing penicilliosis is becoming a major concern for opportunistic infections in immunocompromised individuals in Southeast Asia.
- Research has identified 177 putative MFS transporters related to azole resistance, with particular focus on the Drug:H antiporter 1 subfamily.
- Three specific transporters (MDR1, MDR2, and MDR3) were shown to confer varying levels of drug resistance, with MDR1 providing the widest resistance spectrum against antifungals.
Article Abstract
is a thermally dimorphic fungus that causes penicilliosis, and become the third-most-common opportunistic fungal infection in immunocompromised patients in Southeast Asia. Azoles and amphotericin B have been introduced for the treatment, however, it is important to investigate possible mechanisms of azole resistance for future treatment failure. We identified 177 putative MFS transporters and classified into 17 subfamilies. Among those, members of the Drug:H antiporter 1 subfamily are known to confer resistance to antifungals. Out of 39 paralogs, three (encoded by , and ) were heterologously overexpressed in AD∆ conferred resistance to various drugs and compounds including azoles, albeit to different degrees. MDR1-expressing strain showed resistance to the broadest range of drugs, followed by the MDR3, and MDR2 conferred weak resistance to a limited range of drugs. We conclude that and , may be able to serve as multidrug efflux pumps.
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| http://dx.doi.org/10.1080/09168451.2020.1732185 | DOI Listing |
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