Three new cyathane diterpenoids named stercorins A-C (), including one with unusual 4,9--carbon skeleton, together with two new drimane sesquiterpenoids named stercorins D () and E () were isolated from the liquid cultures of the basidiomycete . Their structures were established by 1D and 2D NMR data in conjunction with HR-ESI-MS. All three cyathane diterpenoids showed neurotrophic activity in PC-12 cells at concentrations of 10 M. Compounds significantly suppressed LPS-induced NO production in culture medium in BV2 cells with the IC values of 1.64 M, 9.25 M and 8.71 M, respectively. Notably, Compound , possessing an uncommon medium-sized 9/7 ring system showed the most promising role in the prevention of two activities-associated neurodegenerative diseases.
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