Background: The case concerns a 30-year-old woman in the 24th week of pregnancy presenting to the medical emergency room with fever and abdominal pain. Urine sediment microscopy revealed the presence of unknown needle-shaped crystals.

Methods: Crystals identification was performed by Fourier-Transform Infrared Spectroscopy coupled to Attenuated Total Reflectance (FTIR-ATR).

Results: Amoxicillin crystals were verified with semiquantitative results of 87.7%.

Conclusions: Drug-induced crystalluria is a frequent finding in urine examination and it may be asymptomatic. FTIR spectroscopy is a rapid and specific tool in identification of crystals and could be useful supporting renal disease diagnosis and monitoring drug therapy.

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2019.190606DOI Listing

Publication Analysis

Top Keywords

amoxicillin crystals
8
identification amoxicillin
4
crystals
4
crystals urine
4
urine case
4
case report
4
report background
4
background case
4
case concerns
4
concerns 30-year-old
4

Similar Publications

Antibiotic-resistant strains of Staphylococcus aureus pose a significant threat in healthcare, demanding urgent therapeutic solutions. Combining bacteriophages with conventional antibiotics, an innovative approach termed phage-antibiotic synergy, presents a promising treatment avenue. However, to enable new treatment strategies, there is a pressing need for methods to assess their efficacy reliably and rapidly.

View Article and Find Full Text PDF

Amoxicillin Blood Concentration in High-Dose Intravenous Discontinuous Amoxicillin: Look Beyond Numbers. Max-Amox Study.

Clin Ther

December 2024

Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:

Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).

View Article and Find Full Text PDF

Amoxicillin crystalluria and amoxicillin-induced crystal nephropathy: a narrative review.

Kidney Int

January 2025

Sorbonne Université, UFR de médecine, Paris, France; Inserm UMR S 1155, Hôpital Tenon, Paris, France; Service des Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, APHP, Paris, France. Electronic address:

Amoxicillin crystalluria (AC) refers to the precipitation of amoxicillin in the urine as amoxicillin trihydrate crystals. Amoxicillin-induced crystal nephropathy (AICN) refers to the obstruction of kidney tubules by amoxicillin trihydrate crystals, resulting in acute kidney injury. Usually considered rare and not serious, AC and AICN would be more frequent in patients receiving high-dose i.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on enhancing photocatalytic activity in carbon nanotubes (CNTs) using organotin(IV) compounds, resulting in hybrid materials (1@CNT and 2@CNT) that generate reactive oxygen species.* -
  • The synthesized compounds were thoroughly characterized using various analytical techniques and showed improved photocatalytic performance compared to bare CNTs due to reduced band gaps and better electron retention.* -
  • Specifically, the hybrid material 1@CNT demonstrated a strong ability to degrade 83% of Amoxicillin under visible light, confirming its effectiveness and stability for environmental remediation over multiple cycles.*
View Article and Find Full Text PDF

In the present report, we have described the synthesis of N-aminopolyhydroquinoline (N-PHQ) derivatives using highly efficient -cyclodextrin (-CD) as a catalyst by the Hantzsch condensation of substituted aromatic aldehydes, dimedone, and hydrazine hydrate in one pot. The reactions were completed in a shorter time without the generation of any other byproduct. The synthesized N-PHQs were washed thoroughly with distilled water and recrystallized with ethanol to get highly purified products (as crystals).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!