Introduction: Our main objective was to evaluate whether antenatal corticosteroids increase the risk of small head circumference in children born at term. Secondary objectives were to evaluate whether they increase the risk of small birthweight and birth length among those children.
Material And Methods: A historical cohort included 275 270 live term born children between 2000 and 2013 in 175 French maternity units. The rate of head circumference below the 5th percentile among children born at term and exposed to antenatal corticosteroids was compared with that of two unexposed groups: those children born at term whose mothers had an episode of threatened preterm labor without corticosteroids and those whose mothers had neither threatened preterm labor nor corticosteroids. The association between this treatment and head circumference was evaluated by calculating adjusted risk ratios (aRRs) and their 95% confidence intervals (CIs). The main outcome measure was a head circumference below the 5th percentile at birth, adjusted for sex, and gestational age according to the Pediatric, Obstetrics, and Gynecology Electronic Records Users Association (AUDIPOG) curves. Secondary outcomes were birthweight and birth length below the 5th percentile.
Results: The rate of head circumference below the 5th percentile was 5.8% (n = 3388) among children exposed to antenatal corticosteroids and 4.3% (n = 7077) and 4.6% (n = 198 462), respectively, for the two unexposed groups. After adjustment, the risk of having a head circumference below the 5th percentile did not differ between the exposed group and the two control groups (aRR 1.28, 95% confidence interval [CI] 0.97-1.69] and aRR 0.91, 95% CI 0.74-1.13). We did not find an association between antenatal corticosteroids and the rate of birthweight below the 5th percentile. Children exposed to antenatal corticosteroids had a higher risk of a birth length below the 5th percentile when compared with those not exposed to threatened preterm labor or corticosteroids.
Conclusions: We found no association between antenatal corticosteroids and increased risk of head circumference below the 5th percentile in children born at term.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/aogs.13839 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Three-dimensional sonographic findings of diprosopus: a case report and literature review.
BMC Pregnancy Childbirth
January 2025
Department of Obstetric and Gynecological Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Background: Diprosopus is one of the rarest anomalies. It typically manifests as bilateral alterations and often involves anomalies within the cranial structures. In this report, we present a case of a fetus with diprosopus diagnosed prenatally.
View Article and Find Full Text PDFPrenatal phenotype of PNKP-related microcephaly, seizures, and developmental delay: A case report and literature review.
Medicine (Baltimore)
January 2025
The Reproductive Medicine Centre, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Rationale: Microcephaly, epilepsy, and developmental delay (MCSZ) is a rare neurodevelopmental disorder associated with autosomal recessive inheritance of mutations in the polynucleotide kinase 3'-phosphatase (PNKP) gene. Prompt identification and management are essential, as delayed diagnosis or intervention may result in severe complications or mortality. In this case, prenatal screening in the second trimester detected fetal microcephaly with a gradual decline in head circumference, prompting the decision to terminate the pregnancy.
View Article and Find Full Text PDFPreterm growth assessment: the latest findings on age correction.
J Perinatol
January 2025
Alberta Health Services, Calgary, Canada.
Objective: To evaluate the effect of age correction up to 36 months of age for growth assessments of extremely preterm (<28 weeks) and very preterm (28 to <32 weeks) infants.
Study Design: This longitudinal analysis used data from the Preterm Infant Multicenter Growth Study (2001-2014).
Results: 1,416 children were included (Median gestational age = 27 weeks).
The mediating role of maternal fasting plasma glucose level and lipid levels in the third trimester of pregnancy between pre-pregnancy BMI and offspring physical development at birth.
Eur J Pediatr
January 2025
School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Unlabelled: While previous research has established correlations between pre-pregnancy body mass index (BMI), late-pregnancy blood glucose, and late-pregnancy blood lipid levels during pregnancy and offspring's physical development, the underlying mechanism of their interaction remains elusive. A birth cohort study was conducted on pregnant women, who are biologically female, delivering at a tertiary hospital in Wuhan City between May 2023 and April 2024, encompassing 1620 participants. We collected maternal socio-demographic data through questionnaires and obtained information on fasting blood glucose (FPG), lipid levels during the third trimester, and neonatal physical development from medical records.
View Article and Find Full Text PDFPrenatal human brain development is not spared by IUGR: A systematic review.
Early Hum Dev
January 2025
School of Medicine, Atenas University Centre, Prefeito Alberto Moura, 6000, 35701-383 Sete Lagoas, MG, Brazil. Electronic address:
Background: Intrauterine growth restriction (IUGR) is a severe condition in which the fetus fails to reach its genetically predetermined growth potential, impairing prenatal development and predisposing individuals to postnatal consequences that may persist into adulthood. Although fetal mechanisms such as the brain-sparing effect have been proposed to protect the brain against IUGR-related deficits, the extent of this protection remains unclear.
Objective: To conduct a systematic review that demonstrates prenatal morphofunctional abnormalities in the brain of individuals with IUGR.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!