Phenolic profile by HPLC-ESI-MS/MS and enzymatic inhibitory effect of .

Nat Prod Res

Curso de Graduação em Farmácia, Sociedade de Educacional Santa Catariana, UniSociesc, Jaraguá do Sul, SC, Brazil.

Published: November 2021

AI Article Synopsis

  • Eckl. & Zeyh., known as the "abyssinian cactus," is a plant native to Madagascar, traditionally used in folk medicine for its analgesic and healing properties.
  • The study involved a phytochemical analysis using HPLC-ESI-MS/MS to identify 27 phenolic compounds, with syringic acid being the most abundant at 87.848 mg/g.
  • Among the extracts, the DCMF fraction demonstrated the most potent biological activity, specifically in inhibiting the α-glucosidase enzyme at a concentration of 0.125 mg/mL.

Article Abstract

(Eckl. & Zeyh.) Druce, native to Madagascar, is popularly known as "abyssian cactus" and popularly used in folk medicine as an analgesic and healing agent. The study methodology was divided into the phytochemical study: fractionation and identification of phenolic compounds by HLPC-ESI-MS/MS from the methanolic extract (ME), and fractions (DCMF and EAF) of leaves of , and biological activity with acetylcholinesterase and α-glucosidase inhibition of extracts and fractions by in vitro enzymatic techniques. Twenty-seven phenolic compounds were identified, being the highest concentration of syringic acid (87.848 mg g). The DCMF fraction showed the best biological activity for inhibition of α-glucosidase enzyme (0.125 mg mL).

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Source
http://dx.doi.org/10.1080/14786419.2020.1729147DOI Listing

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