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Determination of oxyphenisatine and its total ester derivatives content in fermented green plum by ultra performance liquid chromatography-tandem mass spectrometry.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
January 2025
Jiangyin Food Safety Testing Center, Jiangyin, P. R. China.
Illegal additives such as oxyphenisatine and its esters are prevalent in the slimming food industry, necessitating a robust analytical method for their detection. This study presents a novel UPLC-MS/MS method for the rapid and accurate quantification of total oxyphenisatine levels in fermented green plum, following hydrolysis of its esters. An efficient ultrasonic extraction with a methanol and 0.
View Article and Find Full Text PDFDiscovery of quality markers of based on an absorption-based metabolite approach and rapid quantification using polarity-switching UPLC-QQQ-MS/MS.
Front Pharmacol
December 2024
Qinghai-Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China, Southwest Minzu University, Chengdu, China.
Article Synopsis
- Regel (MQ) is a traditional Chinese medicine used for over a thousand years, but its clinical application suffers from a lack of identifiable quality markers that can ensure safety and efficacy.
- An innovative metabolite approach using advanced chromatography techniques was developed to identify and quantify the quality markers of MQ, allowing for a more effective analysis of its pharmacological properties.
- The study identified 13 absorbed compounds and 30 metabolites, with 9 specific compounds correlating with hepatocyte protection and absorption being proposed as quality markers for MQ.
Development of a UHPLC-MS/MS Method for the Determination of Moxidectin in Rat Plasma and Its Application in Pharmacokinetics.
Molecules
October 2024
Key Laboratory of New Animal Drug Project, Gansu Province/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
The aim of the present study was to establish a simple and reliable ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method and apply it for the determination of pharmacokinetics of moxidectin-loaded microspheres (MOX-MS) in rats. Plasma samples were processed using a simplified liquid-liquid extraction method and were separated using an Agilent Zorbax Eclipse Plus C18 column (50 mm × 2.1 mm, 1.
View Article and Find Full Text PDFHigh-performance liquid chromatography-tandem mass spectrometry was used to measure 20 antidepressants in human serum.
Bioanalysis
November 2024
Key Laboratory of Antibody Engineering of Guangdong Higher Education Institutes, Institute of Antibody Engineering, School of Laboratory Medicine & Biotechnology, Southern Medical University, Guangzhou, China.
Article Synopsis
- * Serum samples were treated with a protein precipitant, and specific conditions for fluid separation and analysis were employed to ensure accurate results.
- * The method demonstrated high accuracy and reliability, making it a useful tool for tracking blood drug levels and understanding how medications are metabolized in patients.
[Determination of eight neonicotinoid pesticides in wastewater by solid phase extraction combined with liquid chromatography-tandem mass spectrometry].
Se Pu
September 2024
School of Environment and Spatial Informatics, China University of Mining and Technology, Xuzhou 221116, China.
Neonicotinoid pesticides are a relatively new class of pesticides that have garnered significant attention owing to their potential ecological risks to nontarget organisms. A method combining solid phase extraction with liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) was developed for the rapid and accurate detection of eight neonicotinoid pesticides (dinotefuran, -nitenpyram, thiamethoxam, clothianidin, imidacloprid, imidaclothiz, acetamiprid, and thiacloprid) in wastewater. The chromatographic mobile phase and MS parameters were selected, and a single-factor method was used to determine the optimal column type, extraction volume, sample loading speed, and pH for SPE.
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