Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051148 | PMC |
| http://dx.doi.org/10.1080/23723556.2019.1691905 | DOI Listing |
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