Laser-assisted indocyanine-green imaging (ICG) has a wide range of surgical applications, and has been used in reconstructive surgery to aid in assessing the viability of free tissue transfers and to help predict poor tissue perfusion. However, its indications for use is limited to assessing free flap tissue perfusion, coronary artery perfusion during coronary artery bypass (CABG), and tissue perfusion in diabetic foot ulcers, to name a few. This system has been proven to be a safe, reliable adjunctive modality to assess microvascular compromise or poor perfusion peri-operatively, which could minimize skin necrosis and other post-operative complications (Further et al., 2013). The ability to objectively assess tissue perfusion has led to improved post-operative outcomes in breast, abdominal wall, colorectal, and cardiac surgery. To date, no studies have reviewed the use of ICG in delineating devitalized bone during sternal wound debridement after cardiac surgery. At our institution, we have encountered a cohort of patients with post-cardiac surgery sternal wound infections who have required debridement of infected and devitalized bone. We propose that SPY technology aids in delineating this devitalized bone, and may aid in the timing muscle flap coverage. In this paper, we will demonstrate two cases of patients who had post-operative sternal wound infections after undergoing cardiac surgery for which ICG was used to demarcate debridement zones and subsequent flap coverage. In these cases, ICG allowed for efficient and reliable intraoperative evaluation of bony perfusion and has aided in early adequate debridement and flap coverage.
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http://dx.doi.org/10.1016/j.jpra.2017.12.002 | DOI Listing |
Background: The choroid plexus (ChP) plays a vital role in CSF production and waste clearance. While existing imaging studies have established connections between ChP volume changes and age-related neurodegenerative diseases, a comprehensive investigation into the microstructural and vascular changes associated with aging remains insufficient. This study aims to explore ChP changes in normal aging using diffusion and perfusion MRI in the HCP-Aging dataset to enhance our understanding of age-related microstructural and vascular changes in the ChP.
View Article and Find Full Text PDFJ Neuroimaging
January 2025
Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Introduction: The venous outflow profile (VOP) is a crucial yet often overlooked aspect affecting stroke outcomes. It plays a major role in the physiopathology of acute cerebral ischemia, as it accounts for both the upstream arterial collaterals and cerebral microperfusion. This enables it to circumvent the limitations of various arterial collateral evaluation systems, which often fail to consider impaired autoregulation and its impact on cerebral blood flow at the microcirculatory levels.
View Article and Find Full Text PDFBackground: A multi-center study in Los Angeles (USC), Kansas City (KUMC) and Dallas (UT-SWMC) quantified via predictive modeling the dynamics of cerebral perfusion regulation (CO2 vasoreactivity and cerebral autoregulation) in MCI/AD patients and cognitively normal controls under resting conditions. The goal was to develop model-based physio-markers for accurate diagnosis of MCI and pre-clinical AD, motivated by our previous findings of significant impairment of cerebral perfusion regulation in MCI and mild AD patients.
Method: Continuous spontaneous changes in arterial blood pressure, end-tidal CO2, cerebral blood flow velocity in middle cerebral arteries and cortical tissue oxygenation at lateral prefrontal cortex were recorded over two 6-8 min sessions, separated by session of slow-paced breathing (6 breaths/minute), in 53 MCI (28 APOE4 non-carriers and 25 APOE4 carriers), 33 mild AD patients (13 APOE4 non-carriers and 20 APOE4 carriers) and 74 age/sex-matched cognitively normal controls (50 APOE4 non-carriers and 24 APOE4 carriers).
Background: This study quantified tau binding in the brain with F-PI2620 PET using a non-invasive Image-Derived Input function(IDIF), derived using a new total-body EXPLORER PET/CT scanner (Spencer et al.,2021). Additionally, we explored how PET scan duration influences the quantification of kinetic parameters across brain regions of interest(ROIs) that are vulnerable in Alzheimer's Disease.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Background: Neuroimmune activation plays a critical role in the pathogenesis of Alzheimer disease (AD). 25-hydroxycholesterol (25-HC) is a cholesterol-derived immune-active oxysterol produced almost exclusively by microglia within the CNS through the enzymatic activity of cholesterol 25-hydroxylase (CH25H). 25-HC is a potent modulator of the innate immune response, with excessive production reported to contribute to neuroinflammation and neurodegeneration in certain CNS disease models.
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