Purpose: NPC is a malignant and invasive tumor with the incidence rate of 19/100,000 per year in Zhongshan City, a prefecture city in southern China. Long-term survival analysis on intensity-modulated radiotherapy (IMRT)-based treatment in local prefecture-level hospitals have not been investigated. We aimed to evaluate the 5-year clinical outcomes and prognostic factors of NPC treated with IMRT in Zhongshan City People's Hospital (ZSPH), a prefecture-level hospital in South China.
Patients And Methods: The number of 149 newly diagnosed non-metastatic NPC cases treated with IMRT were included from Zhongshan City People's Hospital between January 2010 and December 2011. The survival outcomes, treatment toxicities and prognostic factors were analyzed by Kaplan-Meier method and Cox proportional hazards model.
Results: With a median follow-up period of 65 months for the cohort, the 5-year local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) and overall survival (OS) were 86.80%, 94.80%, 86.10% and 80.50%, respectively. The 5-year OS rates were 100%, 95.2%, 87% and 67.2% for stage I, II, II and IVa-b, respectively (P=0.004). The 5-year LRFS rates were 97.2%, 96.0%, 90.4% and 72.0% for T1, T2, T3 and T4, respectively (P=0.001); the 5-year DMFS rates were 100% for T1, 96.8% for T2, 81.9% for T3 and 74.6% for T4 (P=0.022). A multivariate analysis revealed tumor stage as an independent prognostic factor for LRFS, DMFS and OS. No patients died from acute toxicities. Late toxicities were observed for 130 (87.2%) patients, and most late toxicities were graded I/II.
Conclusion: NPC treatment effect in a prefecture-level hospital in South China was comparable to international results and toxicities were tolerable. Tumour stage was an independent prognostic factor for survival outcome. More NPC survival data from local and remote places are needed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047969 | PMC |
| http://dx.doi.org/10.2147/CMAR.S237278 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inter-city movement pattern of notifiable infectious diseases in China: a social network analysis.
Lancet Reg Health West Pac
January 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing, PR China.
Background: Co-existence of efficient transportation networks and geographic imbalance of medical resources greatly facilitated inter-city migration of patients of infectious diseases in China.
Methods: To characterize the migration patterns of major notifiable infectious diseases (NIDs) during 2016-2020 in China, we collected migratory cases, who had illness onset in one city but were diagnosed and reported in another, from the National Notifiable Infectious Disease Reporting System, and conducted a nationwide network analysis of migratory cases of major NIDs at the city (prefecture) level.
Findings: In total, 2,674,892 migratory cases of NIDs were reported in China during 2016-2020.
Geographical variation in high-impact chronic pain and psychological associations at the regional level: a multilevel analysis of a large-scale internet-based cross-sectional survey.
Front Public Health
December 2024
Department of Pain Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Background: A geographical analysis could be employed to uncover social risk factors and interventions linked to chronic pain. Nonetheless, geographical variation in chronic pain across different regions of Japan have not been well explored. This study aims to investigate geographical variation in high-impact chronic pain (HICP), defined as moderate to severe chronic pain, and examine the associated psychological factors at the prefecture level.
View Article and Find Full Text PDF[Current situation and demand for specialized development of allergy nursing in eighty-eight hospitals in Guangdong Province].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou510630, China.
To investigate the current situation and demand for specialized development of allergy nursing in 88 hospitals in Guangdong Province, as well as to provide evidence for the management of allergy nursing. From August to December 2023, a cross-sectional study was conducted to analyze the core managers of allergy nursing-related work in eighty-eight hospitals in Guangdong Province supported by the Allergy Nursing Branch of the Guangdong Nurses Association and the Nursing Group of the Allergy Branch of the Guangdong Medical Association. An online survey was conducted using the Delphi method to compile a questionnaire on the current status and demand for specialized development of allergy nursing in Guangdong Province.
View Article and Find Full Text PDFAssociation between ambient particulate matter and latent tuberculosis infection among 198 275 students.
J Glob Health
December 2024
Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China.
Background: Numerous studies have estimated the impact of outdoor particulate matter (PM) on tuberculosis risk. Nevertheless, whether there is an association between ambient PM and latent tuberculosis infection (LTBI) risk remains uncertain.
Methods: We collected the basic information and LTBI test results of students who underwent freshmen enrolment physical examinations in 68 middle schools from six prefecture-level cities located in eastern China between 2018 and 2021.
Effectiveness of a scenario-based, community-based intervention in containing COVID-19 in China.
Front Public Health
December 2024
Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Background: Given the significant impact of the more than three-year-long COVID-19 pandemic on people's health, social order, and economic performance, as well as the potential re-emergence of a new variant and the epidemic "Disease X," it is crucial to examine its developmental trends and suggest countermeasures to address community epidemics of severe respiratory infectious diseases.
Methods: The epidemiological characterization of various strains of COVID-19 was modeled using an improved Susceptible-Exposed-Infectious-Recovered (SEIR) model to simulate the infections of different strains of COVID-19 under different scenarios, taking as an example an urban area of a prefecture-level city in Shandong Province, China, with a resident population of 2 million. Scenarios 1-5 are scenario-based simulations the Omicron strain, and 6-8 simulate the original COVID-19 strain, with different parameters for each scenario.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!