AI Article Synopsis
- The study aimed to examine the immunomodulatory effects of areca nut extract and analyze its phytochemical components.
- The extract was evaluated using high-performance liquid chromatography (HPLC) and tested on 35 rats, revealing that it significantly increased white blood cell counts without adversely affecting other blood parameters or organ functions.
- The findings suggest that the antioxidant properties of areca nuts, particularly from compounds like catechin and quercetin, enhance cellular immunity, making the 1000 mg/kg dosage the most effective.
Article Abstract
Aim: The aim of the study was to investigate the immunomodulatory activity of areca nut extract. The phytochemical content and phenolic composition of the extract were also determined.
Materials And Methods: An extract of areca nut was prepared using 96% ethanol and subsequently screened for phytochemical content using a high-performance liquid chromatography (HPLC) method. The immunomodulatory activity of the extract was tested in 35 Sprague-Dawley rats, divided into four groups: One control group and three experimental groups in which the rats received 500, 1000, or 1500 mg/kg of oral areca nut extract biweekly (BW). The extract was orally administered 14 days before the intraperitoneal challenge with (1×10 CFU/mL). On the 14 day of the experiment, rats in all the four groups were sacrificed. Measurement of the levels of red blood cells, hematocrit (Hct), hemoglobin (Hb), white blood cells (WBCs), lymphocytes, monocytes, neutrophils, basophils, eosinophil, and macrophages were recorded. The activities of serum glutamate oxalate transaminase, serum glutamate pyruvate transaminase, urea, and creatinine were also determined.
Results: Areca nut was found to contain an alkaloid, tannin, and flavonoid compounds. HPLC analysis revealed the presence of catechin as the major compound along with quercetin. Administration of areca nut extract in rats infected with produced a significant increase in the concentration of WBC but did not affect Hct, Hb, and other cell types. Among the different doses tested, 1000 mg/kg BW was found to be most effective in cellular immunity models. No harmful effects on the liver and kidney functions were observed.
Conclusion: The antioxidant activity of areca nut might be attributed to the presence of catechin and quercetin. Administration of areca nut extract increased the number of WBCs and improved the activity and capacity of macrophages significantly in rats infected with .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020107 | PMC |
| http://dx.doi.org/10.14202/vetworld.2020.134-140 | DOI Listing |
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